Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL) [PDF]
Toxins, 2017 Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Natalia Vilariño +2 more
exaly +9 more sources
Scientific Reports, 2023 Ionizing radiations are a helpful technique and have improved financial potential in developing new and unique commercially important fruit tree varieties.
Ali Akbar Ghasemi-Soloklui +2 more
doaj +4 more sources
مجلة الانبار للعلوم البيطرية, 2021 It is very important, before starting the manufacture of any vaccine from any microorganism estimation of LD₅₀ of that microorganism to determine their pathogenicity and virulence.
Abdullah Abdullazeez Sheehan +2 more
doaj +3 more sources
Propidium monoazide PCR, a method to determine OsHV-1 undamaged capsids and to estimate virus Lethal Dose 50 [PDF]
Virus ResearchOstreid herpes virus 1 (OsHV-1) has been classified within the Malacoherpesviridae family from the Herpesvirales order. OsHV-1 is the etiological agent of a contagious viral disease of Pacific oysters, C.
Tristan Renault +2 more
doaj +5 more sources
Confidence limit calculation for antidotal potency ratio derived from lethal dose 50. [PDF]
World J Methodol, 2013 To describe confidence interval calculation for antidotal potency ratios using bootstrap method.We can easily adapt the nonparametric bootstrap method which was invented by Efron to construct confidence intervals in such situations like this. The bootstrap method is a resampling method in which the bootstrap samples are obtained by resampling from the ...
Manage A, Petrikovics I.
europepmc +3 more sources
The acute lethal dose 50 (LD50) of caffeine in albino rats.
Regulatory Toxicology and Pharmacology, 2016 An acute LD50 is a statistically derived amount of a substance that can be expected to cause death in 50% of the animals when given by a specified route as a single dose and the animals observed for a specified time period.
R. Adamson
semanticscholar +3 more sources
Acute Toxicity (Lethal Dose 50 Calculation): Medicine as a Life Saver or Destroyer
International Journal of Advance Research and Innovation, 2019 Lethal dose (LD 50) has been calculated. Different-testing methods have been used. The observed values have been plotted by Dose-Response against measured response and dose. Different LD value shows that all substances are poison. It depend on the amount
M. Chaudhary, Alka, Sajid Ali
semanticscholar +2 more sources
Effect of Linezolid on the 50% Lethal Dose and 50% Protective Dose in Treatment of Infections by Gram-Negative Pathogens in Naive and Immunosuppressed Mice and on the Efficacy of Ciprofloxacin in an Acute Murine Model of Septicemia [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACTMurine models of infection were used to study the effect of linezolid on the virulence of Gram-negative bacteria and to assess potential pharmacodynamic interactions with ciprofloxacin in the treatment of these infections, prompted by observations from a recent clinical trial.
A. Marra +8 more
semanticscholar +3 more sources
Toxicon, 2020 Palytoxin is an emergent toxin in Europe and one of the most toxic substances know to date. The toxin disrupts the physiological functioning of the Na+/K+-ATPase converting the enzyme in a permeant cation channel.
Andrea Boente-Juncal +5 more
semanticscholar +4 more sources
Acute Toxicity (Lethal Dose 50 Calculation) of Herbal Drug Somina in Rats and Mice
Pharmacology & Pharmacy, 2015 Somina (herbal preparation) prepared by Hamdard Laboratories (Waqf) Pakistan is a mixture of five different medicinal plants, widely prescribed for the treatment of mental illness.
Muhammad Ahmed
semanticscholar +3 more sources