Results 41 to 50 of about 346,940 (303)
, 2019 We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy.
Abolfath, Ramin +5 more
core +1 more source
Methanol and isopropanol embryo dosage response curves for wild-type and ethanol-sensitive zebrafish [PDF]
, 2016 It is well established that ethanol has an array of negative effects on developing embryos, from craniofacial abnormalities to cognitive deficits and behavioral disorders.
Anderson, Ashley
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Infectivity decline of an RNA plant virus by increased mutagenesis supports the lethal defection model in vivo [PDF]
, 2013 Lethal mutagenesis is a new antiviral therapy based on increasing the mutation rate by using mutagenic base and nucleoside analogues whose molecular mechanisms are not fully understood.
Brichette Mieg, Isabel +2 more
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015 Aim. Research of the acute toxicity of new compounds could prevent the development of compounds with high pharmacological activity, which exhibit undesirable pharmacological properties.
E. S. Pruglo +2 more
doaj +1 more source
Lassa antiviral LHF-535 protects guinea pigs from lethal challenge
Scientific Reports, 2022 LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa fever, a zoonotic disease endemic in West Africa that generates significant morbidity and mortality.
Kathleen A. Cashman +8 more
doaj +1 more source
Infectivity decline of an RNA plant virus by increased mutagenesis in vivo [PDF]
, 2014 According to the lethal defection model, during lethal mutagenesis viral genomes with a low degree of mutation and low specific infectivity exert an interfering activity that leads to virus loss.
Brichette Mieg, Isabel +2 more
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A critically ill patient after a colchicine overdose below the lethal dose: a case report
Journal of Medical Case Reports, 2018 Background Although 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported.
Ichiro Hirayama +4 more
doaj +1 more source