Results 41 to 50 of about 191,908 (258)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A critically ill patient after a colchicine overdose below the lethal dose: a case report

Journal of Medical Case Reports, 2018
Background Although 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported.
Ichiro Hirayama, Takahiro Hiruma, Yoshihiro Ueda, Kent Doi, Naoto Morimura   +4 more
doaj   +1 more source

Non-Lethal Dose-Response Models Replace Lethal Bioassays for Predicting the Hazard of Para-Aminopropiophenone to Australian Wildlife

Animals, 2023
Para-aminopropiophenone (PAPP) is a potent methaemoglobin (MetHb) forming agent used for the lethal control of exotic carnivores and mustelids. To assess the sensitivity of Australian wildlife to PAPP we developed an in vivo assay that did not use death ...
Clive A. Marks, Lee Allen, Heli Lindeberg   +2 more
doaj   +1 more source

Acute Toxicity (Lethal Dose 50 Calculation) of Herbal Drug Somina in Rats and Mice

Pharmacology & Pharmacy, 2015
Somina (herbal preparation) prepared by Hamdard Laboratories (Waqf) Pakistan is a mixture of five different medicinal plants, widely prescribed for the treatment of mental illness. For acute toxicity, the Karber arithmetic method for the calculation of LD50 and Hodge and Sterner toxicity scale was used. In this study, different doses (10, 100, 285, 500,
openaire   +2 more sources

Alternative Methods for the Median Lethal Dose (LD50) Test: The Up-and-Down Procedure for Acute Oral Toxicity [PDF]

ILAR Journal, 2002
The authors have developed an improved version of the up-and-down procedure (UDP) as one of the replacements for the traditional acute oral toxicity test formerly used by the Organisation for Economic Co-operation and Development member nations to characterize industrial chemicals, pesticides, and their mixtures. This method improves the performance of
Amy, Rispin, David, Farrar, Elizabeth, Margosches, Kailash, Gupta, Katherine, Stitzel, Gregory, Carr, Michael, Greene, William, Meyer, Deborah, McCall   +8 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of lethal and sublethal doses: Comparative toxicity of three commonly used pesticides on Blattella germanica, an important allergen and vector of pathogens

Heliyon
The study investigates the comparative toxicity of three widely used insecticides-fenitrothion, malathion, and deltamethrin-on Blattella germanica, a major urban pest.Using bioassay tests based on World Health Organization (WHO) protocols, we determined ...
Mozaffar Vahedi, Kourosh Azizi, Amin Hosseinpour, Abbasali Raz, Hadi Aligholi, Mohammad Hoseini, Aboozar Soltani   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Punica granatum L. protects mice against hexavalent chromium-induced genotoxicity

Brazilian Journal of Pharmaceutical Sciences, 2013
This study investigated the chemoprotective effects of Punica granatum L. (Punicaceae) fruits alcoholic extract (PGE) on mice exposed to hexavalent chromium [Cr(VI)].
Renato Ivan de Ávila, Meirielle Teixeira Guerra, Kamilla de Almeida Souza Borges, Marcelo de Sousa Vieira, Luiz Marcos de Oliveira Júnior, Humberto Furtado, Mariana Flavia da Mota, Andréa Fernandes Arruda, Marize Campos Valadares   +8 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source