Results 61 to 70 of about 191,908 (258)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Using Ivermectin for treating channel catfish (Ictalurus punctatus) infected with Dollfustrema bagarii

Fisheries and Aquatic Sciences
Channel catfish (Ictalurus punctatus), an introduced species in Vietnam, is widely cultured in the Northern provinces. The off-white grub disease in Channel catfish, caused by metacercariae of Dollfustrema bagarii (Digenea: Bucephalidae) lodged in ...
Manh Duc Vu, Kim Minh Anh, Lua Thi Dang, Hung Manh Nguyen, Trinh Tran Thi, Nhinh Doan Thi, Manh Van Ngo, Kim Van Van   +7 more
doaj   +1 more source

Two Genetically Similar H9N2 Influenza A Viruses Show Different Pathogenicity in Mice

Frontiers in Microbiology, 2016
H9N2 Avian influenza virus has repeatedly infected humans and other mammals, which highlights the need to determine the pathogenicity and the corresponding mechanism of this virus for mammals. In this study, we found two H9N2 viruses with similar genetic
Qingtao Liu, Yuzhuo Liu, Jing Yang, Xinmei Huang, Kaikai Han, Dongmin Zhao, Keran Bi, Yin Li   +7 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Identifying Optimum Herbicide Mixtures to Manage and Avoid Fenoxaprop-p-Ethyl Resistant Phalaris minor in Wheat [PDF]

Planta Daninha, 2016
Use of herbicide mixtures has been advocated as most effective strategy for avoidance and management of herbicide resistant weeds. Effect of twelve selected treatments of four herbicides (clodinafop-propargil, metribuzin, pinoxaden and sulfosulfuron) two-
T. ABBAS, M.A. NADEEM, A. TANVEER, R. AHMAD   +3 more
doaj   +2 more sources

Determination of Lethal Dose 50 for Induced Mutagenesis in Soybean [Glycine max (L.) Merril] cv. Gepak Kuning Through Ethyl Methane Sulfonate Mutagen

Agricultural Science Digest - A Research Journal, 2023
Background: The improvement of the genetic and agronomic properties of cultivated plants can be carried out by various plant breeding methods, including mutation breeding. Mutations in nature are very few and rare. Ethyl Methane Sulfonate (EMS) is a chemical mutagen that can cause random mutations resulting in changes in genetic material.
Nilahayati ., Rd. Selvy Handayani, Nazimah ., Muhammad Sani Alfikri Harahap, Gusti Irawan, Rosmaina .   +5 more
openaire   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The protective effect of polarized, incoherent, polychromatic light on white mice infected with influenza A virus

Journal of Education, Health and Sport, 2017
Under the influence of polarized light, the reproduction of the influenza A virus in the mice has been slowed. The survival rate of mice infected with a lethal dose of influenza A virus was 50%, compared to the control group.
N. A. Mamedaliev, V. A. Divocha
doaj   +3 more sources

Effects of the European hornet ( Vespa crabro Linnaeus 1761) crude venom on its own species

Journal of Venomous Animals and Toxins including Tropical Diseases, 2013
Background Lethal dose 50% is a classical index of toxicity that usually employs small rodents as experimental animals. Therefore, scarce data are available on the effects of venom on invertebrates, particularly the impact of wasp venom on its own ...
Jerzy Nadolski
doaj   +1 more source