Results 51 to 60 of about 191,908 (258)

Mutagenic effectiveness, efficiency and dose optimization of gamma rays in papaya (Carica papaya L.) varieties

Electronic Journal of Plant Breeding, 2022
The present study was conducted to determine the mutagenic effectiveness, efficiency and lethal dose of gamma rays in papaya varieties CO7, Arka Prabhath and Arka Surya. Papaya seeds were exposed to various doses of gamma rays (0Gy, 100Gy, 150Gy, 200Gy,
Aiswarya Ravi1*, M. S. Aneesa Rani2, J. Auxcilia3, V. Thiruvengadam4 and G. Karthikeyan5
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessment of the Antinociceptive, Anti-Inflammatory, and Acute Toxicity Effects of Solanum Dulcamara Essential Oil in Male Mice

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2020
BACKGROUND AND OBJECTIVE: Pain is a complex set of unpleasant sensory, emotional, and cognitive experiences that are relieved with synthetic and herbal remedies. Of course, medicinal plants are more important than chemical drugs due to fewer side effects.
AR Fallahzadeh, S Mohammadi
doaj  

Lethal and Sublethal Effects of Fluxametamide on Rice-Boring Pest, Rice Stem Borer Chilo suppressalis

Agronomy, 2022
(1) Background: Fluxametamide is a novel isoxazoline insecticide. Rice stem borer Chilo suppressalis (Walker) is a destructive Lepidoptera pest of rice in China, and novel effective insecticides are required to be developed for controlling it due to its ...
Yao Li, Yingnan Wang, Chenglong Qian, Tao Tang, Ning Shen, Wei Wu, Jianming Wang, Zhaojun Han, Chunqing Zhao   +8 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Acute and Lethal Dose Toxicity Test of Pure Eel Fish (Anguilla marmorata [Q.] Gaimard) Oil in Mice (Mus musculus)

Journal of Public Health and Pharmacy
Introduction: Eel fish oil (Anguilla marmorata (Q.) Gaimard) highlighted its nutritional advantages, especially vitamin A, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), and omega-3.
Jamaluddin Jamaluddin, Ihwan Ihwan, Khildah Khaerati, Asriani Hasanuddin, Novalina Serdiati, Jusri Nilawati, Berniawan Wijaya, Yuliet Yuliet, Iftitah Ahmad   +8 more
doaj   +1 more source

Acute effects of methcathinone and manganese in mice: A dose response study

Heliyon, 2019
An intravenously injectable illicit drug made by mixing pseudoephedrine, potassium permanganate, vinegar and water, yielding methcathinone (Mcat) and manganese (Mn), induces an extrapyramidal syndrome with parkinsonism, dystonia, gait and balance ...
Andres Asser, Sulev Kõks, Ursel Soomets, Anton Terasmaa, Martin Sauk, Mall Eltermaa, Piret Piip, Kumari Ubhayasekera, Jonas Bergquist, Pille Taba   +9 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Characterization of food color additives and evaluation of their acute toxicity in Wistar albino rats [PDF]

Veterinary World
Background and Aim: The use of food dyes can cause certain diseases, such as anemia and indigestion, along with other disorders, tumors, and even cancer.
D. A. Qasim, I. J. Lafta
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source