Results 71 to 80 of about 5,585,699 (313)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Acute and Lethal Dose Toxicity Test of Pure Eel Fish (Anguilla marmorata [Q.] Gaimard) Oil in Mice (Mus musculus)

Journal of Public Health and Pharmacy
Introduction: Eel fish oil (Anguilla marmorata (Q.) Gaimard) highlighted its nutritional advantages, especially vitamin A, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), and omega-3.
Jamaluddin Jamaluddin, Ihwan Ihwan, Khildah Khaerati, Asriani Hasanuddin, Novalina Serdiati, Jusri Nilawati, Berniawan Wijaya, Yuliet Yuliet, Iftitah Ahmad   +8 more
doaj   +1 more source

Punica granatum L. protects mice against hexavalent chromium-induced genotoxicity

Brazilian Journal of Pharmaceutical Sciences, 2013
This study investigated the chemoprotective effects of Punica granatum L. (Punicaceae) fruits alcoholic extract (PGE) on mice exposed to hexavalent chromium [Cr(VI)].
Renato Ivan de Ávila, Meirielle Teixeira Guerra, Kamilla de Almeida Souza Borges, Marcelo de Sousa Vieira, Luiz Marcos de Oliveira Júnior, Humberto Furtado, Mariana Flavia da Mota, Andréa Fernandes Arruda, Marize Campos Valadares   +8 more
doaj   +1 more source

A modified arithmetical method of Reed and Muench for determination of a relatively ideal median lethal dose (LD50)

, 2011
Reed L.J. and Muench H. introduced arithmetical method for determination of median lethal dose (LD50) in 1938. Since then the same method has not been revised for better precision and accuracy.
A. Saganuwan
semanticscholar   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Analysis of lethal and sublethal doses: Comparative toxicity of three commonly used pesticides on Blattella germanica, an important allergen and vector of pathogens

Heliyon
The study investigates the comparative toxicity of three widely used insecticides-fenitrothion, malathion, and deltamethrin-on Blattella germanica, a major urban pest.Using bioassay tests based on World Health Organization (WHO) protocols, we determined ...
Mozaffar Vahedi, Kourosh Azizi, Amin Hosseinpour, Abbasali Raz, Hadi Aligholi, Mohammad Hoseini, Aboozar Soltani   +6 more
doaj   +1 more source

Mutagenic effectiveness, efficiency and dose optimization of gamma rays in papaya (Carica papaya L.) varieties

Electronic Journal of Plant Breeding, 2022
The present study was conducted to determine the mutagenic effectiveness, efficiency and lethal dose of gamma rays in papaya varieties CO7, Arka Prabhath and Arka Surya. Papaya seeds were exposed to various doses of gamma rays (0Gy, 100Gy, 150Gy, 200Gy,
Aiswarya Ravi1*, M. S. Aneesa Rani2, J. Auxcilia3, V. Thiruvengadam4 and G. Karthikeyan5
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Median lethal dose (LD₅₀) of WRK on cancer cell lines tested.

, 2016
Median lethal dose (LD50) of WRK on cancer cell lines tested.
Jacques Augenstreich (3106434), Julien Verdon (2275399), Etienne Harté (2459764), Sophie Lecomte (125153), Jean-Marc Berjeaud (476101), Marc Mesnil (3106428), Clémence Loiseau (3106425), Martine Garcia (3106431), Adrienne Marchand (153278)   +8 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source