Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism [PDF]
Scientific Reports, 2021 Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell ...
Alexandra J. Machen +2 more
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An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice [PDF]
Communications BiologyAcute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as ...
Shuto Tanaka +14 more
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CD4+ T cells targeting dominant and cryptic epitopes from Bacillus anthracis Lethal Factor [PDF]
Frontiers in Microbiology, 2016 Anthrax is an endemic infection in many countries, particularly in the developing world. The causative agent, Bacillus anthracis, mediates disease through the secretion of binary exotoxins.
Stephanie eAscough +11 more
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Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. [PDF]
PLoS Pathogens, 2012 NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms.
Jonathan L Levinsohn +8 more
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Rational Drug Designing Strategies and Inhibitor Optimization: Anthrax Lethal Toxin Factor [PDF]
International Journal Bioautomation, 2012 Anthrax toxin protein protective antigen, edema factor and lethal factor are secreted by Bacillus anthracis bacteria causes several adverse effects on human as well as on ruminant animals and considered as serious biological weapons. Lethal toxin protein
Pawan Kumar Jayaswal +2 more
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Lethal Factor and Anti-Protective Antigen IgG Levels Associated with Inhalation Anthrax, Minnesota, USA [PDF]
Emerging Infectious Diseases, 2014 Bacillus anthracis was identified in a 61-year-old man hospitalized in Minnesota, USA. Cooperation between the hospital and the state health agency enhanced prompt identification of the pathogen.
Mark D. Sprenkle +9 more
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Prospects for the use of Bacillus anthracis toxin in cancer therapy
Ветеринария сегодня, 2022 Cancer is one of the major causes of death in pet animals and humans worldwide. The contraindications and side effects associated with conventional cancer therapies heighten the importance of research aimed at finding new ways to combat cancer.
A. P. Rodionov +3 more
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Anthrax Toxin Detection: From In Vivo Studies to Diagnostic Applications
Microorganisms, 2020 Anthrax toxins are produced by Bacillus anthracis throughout infection and shape the physiopathogenesis of the disease. They are produced in low quantities but are highly efficient.
Jean-Nicolas Tournier +1 more
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Anthrax lethal factor inhibition [PDF]
Proceedings of the National Academy of Sciences, 2005 The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways, cell destruction, and circulatory shock. Inhibition of this proteolytic-based LF toxemia could
W L, Shoop +23 more
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Pathogens, 2020 : Prompt and accurate detection of Bacillus anthracis spores is crucial in the event of intentional spore dissemination in order to reduce the number of expected casualties.
Efi Makdasi +5 more
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