Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. [PDF]
PLoS ONE, 2012 Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin.
Kristina A Hellmich +8 more
doaj +1 more source
Capturing the transcription factor interactome in response to sub-lethal insecticide exposure
Current Research in Insect Science, 2021 The increasing levels of pesticide resistance in agricultural pests and disease vectors represents a threat to both food security and global health. As insecticide resistance intensity strengthens and spreads, the likelihood of a pest encountering a sub ...
Victoria A Ingham +3 more
doaj +1 more source
Role of N-terminal amino acids in the potency of anthrax lethal factor. [PDF]
PLoS ONE, 2008 Anthrax lethal factor (LF) is a Zn(+2)-dependent metalloprotease that cleaves several MAPK kinases and is responsible for the lethality of anthrax lethal toxin (LT). We observed that a recombinant LF (LF-HMA) which differs from wild type LF (LF-A) by the
Pradeep K Gupta +4 more
doaj +1 more source
Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma [PDF]
, 1998 Macrophage migration inhibitory factor (MIF) is a potent proinflammatory mediator that has been shown to potentiate lethal endotoxemia and to play a potentially important regulatory role in human acute respiratory distress syndrome (ARDS).
N Hirani +15 more
core +1 more source
Biosensors, 2021 Anthrax lethal factor (LF) is one of the enzymatic components of the anthrax toxin responsible for the pathogenic responses of the anthrax disease. The ability to screen multiplexed ligands against LF and subsequently estimate the effective kinetic rates
Allison M. Marn +3 more
doaj +1 more source
Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection [PDF]
, 1993 Interferon gamma (IFN) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission.
Crnkovic, Irena +5 more
core +1 more source
Toxins, 2012 Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward ...
Judith A. James +8 more
doaj +1 more source
The Relationship Between a Person's Criminal History, Immediate Situational Factors, and Lethal Versus Non-Lethal Events [PDF]
, 2015 When investigating serious violence, studies tend to look primarily at offenders and their background. This study investigates the influence of offenders' and victims' criminal history and immediate situational factors on the likelihood that violent ...
Nieuwbeerta, P. +10 more
core +1 more source
Anthrax Lethal Toxin and the Induction of CD4 T Cell Immunity
Toxins, 2012 Bacillus anthracis secretes exotoxins which act through several mechanisms including those that can subvert adaptive immunity with respect both to antigen presenting cell and T cell function.
Daniel M. Altmann +2 more
doaj +1 more source
Antibodies against Anthrax: Mechanisms of Action and Clinical Applications
Toxins, 2011 B. anthracis is a bioweapon of primary importance and its pathogenicity depends on its lethal and edema toxins, which belong to the A-B model of bacterial toxins, and on its capsule.
Thibaut Pelat +2 more
doaj +1 more source