Results 51 to 60 of about 3,844,636 (291)

Lethality by pneumonia and factors associated to death

Jornal de Pediatria (Versão em Português), 2014
To describe the case-fatality rate (CFR) and risk factors of death in children with community-acquired acute pneumonia (CAP) in a pediatric university hospital.A longitudinal study was developed with prospective data collected from 1996 to 2011. Patients aged 1 month to 12 years were included in the study.
Ferreira, Sidnei, Sant'Anna, Clemax C., March, Maria de Fátima B.P., Santos, Marilene Augusta R.C., Cunha, Antonio Jose Ledo A.   +4 more
openaire   +7 more sources

Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]

, 2013
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
Maria Scarselli (247406), Norais Nathalie, Jeffrey T. Rubino (490079), Norais, Nathalie, Leuzzi, Rosanna, Massimiliano Biagini, Biagini Massimiliano, Martinelli Manuele, Scarselli, Maria, Jeffrey T Rubino, Serruto Davide, Manuele Martinelli, Rosanna Leuzzi (490078), Nathalie Norais, Davide Serruto, Rosanna Leuzzi, Rubino, Jeffrey T., Nathalie Norais (159651), Serruto, Davide, Unnikrishnan, Meera, Manuele Martinelli (272421), Cantini Francesca, Francesca Cantini, Maria Scarselli, Martinelli, Manuele, Cantini, Francesca, Biagini, Massimiliano, Meera Unnikrishnan, Rubino Jeffrey T., Valeria Cafardi (490077), Massimiliano Biagini (247421), Unnikrishnan Meera, Cafardi, Valeria, Leuzzi Rosanna, Cafardi Valeria, Valeria Cafardi, Meera Unnikrishnan (183268), Scarselli Maria, Francesca Cantini (208272), Davide Serruto (148434)   +39 more
core   +1 more source

Antibodies against Anthrax: Mechanisms of Action and Clinical Applications

Toxins, 2011
B. anthracis is a bioweapon of primary importance and its pathogenicity depends on its lethal and edema toxins, which belong to the A-B model of bacterial toxins, and on its capsule.
Thibaut Pelat, Philippe Thullier, Jeffrey W. Froude II   +2 more
doaj   +1 more source

Late-acting dominant lethal genetic systems and mosquito control. [PDF]

, 2007
BACKGROUND: Reduction or elimination of vector populations will tend to reduce or eliminate transmission of vector-borne diseases. One potential method for environmentally-friendly, species-specific population control is the Sterile Insect Technique (SIT)
Epton Matthew J, Gavin Pape, Guoliang Fu, Phuc, HK, Coleman Paul G, Burton, RS, Fu, G, Pape, G, Kirsty C Condon, Paul G Coleman, Fu, Guoliang, Phuc Hoang, Donnelly, CA, Coleman, Paul G, Andreasen, Morten H, Burton Rosemary S, Fu Guoliang, Pape, Gavin, Donnelly Christl A, White-Cooper, Helen, Scaife Sarah, Donnelly, Christl A, Coleman, PG, White-Cooper, H, White-Cooper Helen, Scaife, Sarah, Vass, Céline, Condon, Kirsty C, Phuc, Hoang Kim, Alphey, Luke, Andreasen, MH, Sarah Scaife, Luke Alphey, Condon, KC, Condon Kirsty C, Céline Vass, Scaife, S, Alphey, L, Helen White-Cooper, Christl A Donnelly, Vass Céline, Alphey Luke, Vass, C, Rosemary S Burton, Pape Gavin, Hoang Phuc, Epton, MJ, Epton, Matthew J, Burton, Rosemary S, Andreasen Morten H, Morten H Andreasen, Matthew J Epton   +51 more
core   +1 more source

tcampbell3/Black-Lives-Matter-Lethal-Force: Black Lives Matter's Effect on Police Lethal Use-of-Force Data and Replication Files (working paper)

, 2021
Data and replications files for working paper Campbell (2021) Black Lives Matter's Effect on Police Lethal Use-of ...
Travis Campbell
core   +1 more source

Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge. [PDF]

Am J Pathol, 2014
Inhalational anthrax is caused by inhalation of Bacillus anthracis spores. The ability of B. anthracis to cause anthrax is attributed to the plasmid-encoded A/B-type toxins, edema toxin (edema factor and protective antigen) and lethal toxin (lethal ...
Hutt JA, Lovchik JA, Drysdale M, Sherwood RL, Brasel T, Lipscomb MF, Lyons CR.   +6 more
europepmc   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Ribosomal Elongation Factor 4 Promotes Cell Death Associated with Lethal Stress

mBio, 2014
Ribosomal elongation factor 4 (EF4) is highly conserved among bacteria, mitochondria, and chloroplasts. However, the EF4-encoding gene, lepA, is nonessential and its deficiency shows no growth or fitness defect. In purified systems, EF4 back-translocates
Liping Li, Yuzhi Hong, Gan Luan, Michael Mosel, Muhammad Malik, Karl Drlica, Xilin Zhao   +6 more
doaj   +1 more source