Results 41 to 50 of about 326,608 (291)
Antibodies against Anthrax: Mechanisms of Action and Clinical Applications
Toxins, 2011 B. anthracis is a bioweapon of primary importance and its pathogenicity depends on its lethal and edema toxins, which belong to the A-B model of bacterial toxins, and on its capsule.
Thibaut Pelat +2 more
doaj +1 more source
Lethality by pneumonia and factors associated to death
Jornal de Pediatria (Versão em Português), 2014 To describe the case-fatality rate (CFR) and risk factors of death in children with community-acquired acute pneumonia (CAP) in a pediatric university hospital.A longitudinal study was developed with prospective data collected from 1996 to 2011. Patients aged 1 month to 12 years were included in the study.
Ferreira, Sidnei +4 more
openaire +7 more sources
, 1998 Macrophage migration inhibitory factor (MIF) is a potent proinflammatory mediator that has been shown to potentiate lethal endotoxemia and to play a potentially important regulatory role in human acute respiratory distress syndrome (ARDS).
N Hirani +15 more
core +1 more source
Lethal factor released from submandibular grafts in mice
, 1969 The present series of experiments clearly demonstrates the existence of the lethal factor in the submandibular gland of male BALB/c mice. This lethal factor was released from the submandibular gland of male mice when the glands were transplanted ...
K. Hoshino, C. D. Lin
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection [PDF]
, 1993 Interferon gamma (IFN) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission.
Crnkovic, Irena +5 more
core
, 2002 Anthrax toxin consists of three proteins, protective antigen, lethal factor, and edema factor. Protective antigen translocates lethal factor and edema factor to the cytosol of mammalian cells.
Bhatnagar, Rakesh +3 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Ribosomal Elongation Factor 4 Promotes Cell Death Associated with Lethal Stress
mBio, 2014 Ribosomal elongation factor 4 (EF4) is highly conserved among bacteria, mitochondria, and chloroplasts. However, the EF4-encoding gene, lepA, is nonessential and its deficiency shows no growth or fitness defect. In purified systems, EF4 back-translocates
Liping Li +6 more
doaj +1 more source