Results 51 to 60 of about 326,608 (291)
Toxin and lethal factor domains found in N11P.
, 2015 Toxin and lethal factor domains found in N11P.
Susan Weininger (694460) +1 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Occurrence of lethal bleeding in factor VIII deficient mice.
, 2016 Occurrence of lethal bleeding in factor VIII deficient mice.
Molly J. Pollpeter (2657014) +1 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Efficient synthetic inhibitors of anthrax lethal factor
, 2005 Inhalation anthrax is a deadly disease for which there is currently no effective treatment. Bacillus anthracis lethal factor (LF) metalloproteinase is an integral component of the tripartite anthrax lethal toxin that is essential for the onset and ...
J. W. SMITH +14 more
core +2 more sources
Lethality-Associated Factors in Deliberate Self-Poisoning
Journal of the Korean Academy of Child and Adolescent Psychiatry, 2021 Deliberate self-poisoning (DSP) is the most common suicide method and can be life-threatening. The purpose of this study was to investigate the factors related to the lethality of DSP and the characteristics of the adolescent group.A retrospective study was conducted on patients who had visited an academic hospital's regional emergency medical center ...
In Young Choi +7 more
openaire +4 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. [PDF]
PLoS Pathogens, 2007 The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse effects. B.
Darly J Manayani +12 more
doaj +1 more source
Species and strain differences in the lethal factor of the mouse submandibular gland
, 1977 The differences in susceptibility of animals to the lethal factor extracted from the mouse submandibular gland and magnitude of its lethality were compared among various species, strains, ages, and sex of mice.
Y. T. Kim +3 more
core +1 more source