Results 91 to 100 of about 988,812 (316)

Anthrax Toxin-Expressing Bacillus cereus Isolated from an Anthrax-Like Eschar. [PDF]

PLoS ONE, 2016
Bacillus cereus isolates have been described harboring Bacillus anthracis toxin genes, most notably B. cereus G9241, and capable of causing severe and fatal pneumonias. This report describes the characterization of a B.
Chung K Marston, Hisham Ibrahim, Philip Lee, George Churchwell, Megan Gumke, Danielle Stanek, Jay E Gee, Anne E Boyer, Maribel Gallegos-Candela, John R Barr, Han Li, Darbi Boulay, Li Cronin, Conrad P Quinn, Alex R Hoffmaster   +14 more
doaj   +1 more source

Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process.

Journal of Biological Chemistry, 1986
Anthrax lethal toxin, which consists of two proteins, protective antigen and lethal factor, is lethal for experimental animals. This study describes the first in vitro system demonstrating lethality of the toxin.
A. Friedlander
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]

, 1990
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Weller, U., Nordmann, J. J., Dayanithi, G., Ahnert-Hilger, G., Gratzl, Manfred   +4 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Susceptibility to Anthrax Lethal Toxin-Induced Rat Death Is Controlled by a Single Chromosome 10 Locus That Includes rNlrp1

PLoS Pathogens, 2010
Anthrax lethal toxin (LT) is a bipartite protease-containing toxin and a key virulence determinant of Bacillus anthracis. In mice, LT causes the rapid lysis of macrophages isolated from certain inbred strains, but the correlation between murine ...
Zachary Newman, M. Printz, Shihui Liu, D. Crown, Laura Breen, Sharmina Miller-Randolph, P. Flodman, S. Leppla, M. Moayeri   +8 more
semanticscholar   +1 more source

Effects of anthrax lethal toxin on human primary keratinocytes [PDF]

Journal of Applied Microbiology, 2008
To investigate the effects of anthrax lethal toxin (LeTx) on human primary keratinocytes.We show here that human primary keratinocytes are resistant to LeTx-triggered cytotoxicity. All but one of the MEKs (mitogen-activated protein kinase kinases) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome ...
S S, Koçer, M, Matic, M, Ingrassia, S G, Walker, E, Roemer, G, Licul, S R, Simon   +6 more
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Select human anthrax protective antigen (PA) epitope-specific antibodies provide protection from lethal toxin challenge

Journal of Infectious Diseases, 2010
Bacillus anthracis remains a serious bioterrorism concern, and the currently licensed vaccine remains an incomplete solution for population protection from inhalation anthrax and has been associated with concerns regarding efficacy and safety.
Sherry R. Crowe, Linda L. Ash, R. Engler, J. Ballard, J. Harley, A. D. Farris, Judith A. James   +6 more
semanticscholar   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source