Results 101 to 110 of about 988,812 (316)

Correction: Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo

PLoS Pathogens, 2008
The authors also acknowledge support for this work from National Institutes of Health grant AI48489.
Heather M Scobie, Darran J Wigelsworth, John M Marlett, Diane Thomas, G. Jonah A Rainey, D. Borden Lacy, Marianne Manchester, R. John Collier, John A. T Young   +8 more
doaj   +2 more sources

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

The actions of Pasteurella multocida toxin on neuronal cells [PDF]

, 2014
Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Lax, Alistair; id_orcid, Robbins, Jon, Duricki, DA, Surguy, SM, Duricki, Denise A., Duricki, Denise, Lax, AJ, Reilly, JM, Reilly, Joanne, Surguy, Susan, Surguy, Susan M., Reilly, Joanne M., Robbins, J, Lax, Alistair J.   +13 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma

Journal of Molecular Biology, 2010
Anthrax is caused by strains of Bacillus anthracis that produce two key virulence factors, anthrax toxin (Atx) and a poly-γ-D-glutamic acid capsule. Atx is comprised of three-proteins: protective antigen (PA) and two enzymes, lethal factor (LF) and edema
A. Kintzer, H. J. Sterling, Iok I. Tang, A. Abdul-Gader, A. Miles, B. Wallace, E. Williams, B. Krantz   +7 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Constitutive expression of Vr-ERE gene in transformed grapevines confers enhanced resistance to eutypine, a toxin from Eutypa lata [PDF]

, 2003
Eutypine (4-hydroxy-3-[3-methyl-3-butene-1-ynyl] benzaldehyde) is a toxin produced by Eutypa lata , the causal agent of eutypa dieback of grapevines.
Bouquet, Alain, Dalmayrac, Sylvie, Roustan, J.P., Legrand, Valérie, Dalmayrac, S., Alain Bouquet, Mondher Bouzayen, Sylvie Dalmayrac, Legrand, V., Bouzayen, M., Alain Latché, Bouzayen, Mondher, Roustan, Jean-Paul, Jean Fallot, Latché, Alain, Torregrosa, Laurent, Pech, Jean-Claude, Laurent Torregrosa, Pech, J.C., Fallot, Jean, Valérie Legrand, Jean-Claude Pech, Jean-Paul Roustan, Bouquet, A.   +23 more
core   +1 more source

Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin

Toxins, 2010
Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax,
Jennifer Bromberg-White, Chih-Shia Lee, Nicholas Duesbery   +2 more
doaj   +1 more source

Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages

Biochemical and Biophysical Research Communications - BBRC, 2010
Anthrax lethal toxin (LT) is an important virulence factor for Bacillus anthracis. In mice, LT lyses macrophages from certain inbred strains in less than two hours by activating the Nlrp1b inflammasome and caspase-1, while macrophages from other strains ...
Zachary Newman, D. Crown, S. Leppla, M. Moayeri   +3 more
semanticscholar   +1 more source