Results 121 to 130 of about 988,812 (316)

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source

Protection of TcdA rRBD against lethal toxin A challenge.

, 2015
(A) BALB/c mice were challenged with a lethal dose of toxin A two weeks after three immunizations with TcdA rRBD (0.3, 3, and 30 μg) via intramuscular injection.
Pele Choi-Sing Chong (314717), Chi-Chang Chen (783029), Leung-Kei Siu (407937), Jui-Hsin Huang (783026), Zhe-Qing Shen (783027), Shu-Pei Lien (783028), Chih-Hsiang Leng (315469), Kuang-Nan Hsiao (296109)   +7 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]

, 2007
Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Evelyn Fuchs, Francis A. Barr, Yoshimura, S. I., Spooner, Robert A., Haas, A. K., Robert A. Spooner, Shin-ichiro Yoshimura, Hass, Alexander K., Fuchs, Evelyn, Lord, Mike, Barr, F. A., Fuchs, E., Lord, J. M., Haas, Alexander K., Spooner, R. A., J. Michael Lord, Alexander K. Haas, Yoshimura, Shin-ichiro, Barr, Francis A.   +18 more
core   +1 more source

Anthrax Lethal Toxin Impairs IL-8 Expression in Epithelial Cells through Inhibition of Histone H3 Modification

PLoS Pathogens, 2009
Lethal toxin (LT) is a critical virulence factor of Bacillus anthracis, the etiological agent of anthrax, whose pulmonary form is fatal in the absence of treatment. Inflammatory response is a key process of host defense against invading pathogens.
B. Raymond, E. Batsché, F. Boutillon, Yong-Zheng Wu, D. Leduc, V. Balloy, E. Raoust, C. Muchardt, P. Goossens, L. Touqui   +9 more
semanticscholar   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Botulinum toxin-A for the treatment of overactive bladder: UK contributions [PDF]

, 2013
Background: Botulinum toxin-A (BoNT/A) is now established second-line management for refractory overactivebladder (OAB) and recognised in many incontinence guidelines and pathways.
Fowler, CJ, Panicker, J. N., Fowler, C. J., Dowson, C, Khan, MS, Seth, JH, Dasgupta, P, Dasgupta, P., Panicker, JN, Sahai, A, Dowson, C., Seth, J. H., Khan, M. S., Sahai, Arun   +13 more
core   +1 more source

Introduction to the Toxins Special Issue “Ricin Toxins”

Toxins, 2019
Ricin toxin isolated from the castor bean (Ricinus communis) is one of the most potent and lethal molecules known [...]
Nilgun E. Tumer
doaj   +1 more source

Structural dynamics of the CROPs domain control stability and toxicity of Paeniclostridium sordellii lethal toxin. [PDF]

Nat Commun, 2023
Zhou Y, Zhan X, Luo J, Li D, Zhou R, Zhang J, Pan Z, Zhang Y, Jia T, Zhang X, Li Y, Tao L.   +11 more
europepmc   +1 more source

The Heart Is an Early Target of Anthrax Lethal Toxin in Mice: A Protective Role for Neuronal Nitric Oxide Synthase (nNOS)

PLoS Pathogens, 2009
Anthrax lethal toxin (LT) induces vascular insufficiency in experimental animals through unknown mechanisms. In this study, we show that neuronal nitric oxide synthase (nNOS) deficiency in mice causes strikingly increased sensitivity to LT, while ...
M. Moayeri, D. Crown, D. Dorward, D. Gardner, J. Ward, Yan Li, Xi-Zhong Cui, P. Eichacker, Stephen H. Leppla   +8 more
semanticscholar   +1 more source