Results 111 to 120 of about 988,812 (316)

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Toxin and lethal factor domains found in N11P.

, 2015
Toxin and lethal factor domains found in N11P.
Susan Weininger (694460), Arthur Weininger (694459)   +1 more
core   +1 more source

Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p [PDF]

, 2012
Background Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes.
Lynne M. Roberts (150050), J Michael Lord, Roberts Lynne M., Spooner, Robert A., Hampton Randolph Y., Lord J. Michael, Robert A. Spooner (150027), Spooner Robert A., Lord, J. Michael, Shuyu Li (18735), Roberts, Lynne M., Randolph Y Hampton, Lynne M Roberts, Shuyu Li, Lord, Mike, J. Michael Lord (150042), Li, Shuyu, Roberts, L. M. (Lynne M.), Robert A Spooner, Randolph Y. Hampton (150034), Li Shuyu, Hampton, Randolph Y.   +21 more
core   +2 more sources

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Neutrophil Elastase Mediates Pathogenic Effects of Anthrax Lethal Toxin in the Murine Intestinal Tract

, 2010
Neutrophils isolated from BALB/c or C57BL/6 mice and treated in vitro with anthrax lethal toxin release bioactive neutrophil elastase, a proinflammatory mediator of tissue destruction. Similarly, neutrophils isolated from mice treated with anthrax lethal
Roger D. Auth, David M. Frucht, Chen Sun, Hui Fang, Robert J. Owen, Lixin Xu, Philip J. Snoy   +6 more
core   +1 more source

Patient-Reported Side Effects of Intradetrusor Botulinum Toxin Type A for Idiopathic Overactive Bladder Syndrome [PDF]

, 2010
Objective: The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Patients and Methods: Botulinum toxin A injection
Mayer, Margit E., Yasmin Hocaoglu, Alexander Buchner, Hocaoglu, Yasmin, Buchner, Alexander, Christian G. Stief, Bauer, Ricarda M., Alexander Roosen, Stief, Christian G., May, Florian, Christian Gratzke, Ricarda M. Bauer, Margit E. Mayer, Gratzke, Christian, Florian May, Roosen, Alexander   +15 more
core   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Characterization of Staphylococcus aureus Enterotoxin L [PDF]

, 2003
Staphylococcus aureus causes a wide variety of diseases. Major virulence factors of this organism include enterotoxins (SEs) that cause both food poisoning and toxic shock syndrome.
Bohach, G. A., Gutierrez, J. A., Orwin, Paul M., Fitzgerald, Ross; id_orcid, Fitzgerald, J. Ross, Schlievert, Patrick M., Orwin, P. M., Bohach, Gregory A., Schlievert, P. M., Leung, D. Y. M., Leung, Donald Y. M., Gutierrez, Juan A.   +11 more
core   +1 more source

The Role of NF-κB and H3K27me3 Demethylase, Jmjd3, on the Anthrax Lethal Toxin Tolerance of RAW 264.7 Cells

PLoS ONE, 2010
Background In Bacillus anthracis, lethal toxin (LeTx) is a critical virulence factor that causes immune suppression and toxic shock in the infected host.
N. Das, K. Jung, Y. Chai
semanticscholar   +1 more source

Internalization and Processing of Bacillus anthracis Lethal Toxin by Toxin-sensitive and -resistant Cells

Journal of Biological Chemistry, 1989
Anthrax lethal toxin consists of two separate proteins, protective antigen and lethal factor (LF). Certain macrophages and a mouse macrophage-like cell line, J774A.1, are lysed by low concentrations of lethal toxin. In contrast, another macrophage cell line, IC-21, and all other cell types tested were resistant to this toxin.
Y, Singh, S H, Leppla, R, Bhatnagar, A M, Friedlander   +3 more
openaire   +2 more sources