Results 91 to 100 of about 603,709 (398)

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

Thermodynamics of binary and ternary complexes of 3-amino-1,2,4-triazole and amino acids with Ni(II) and Co(II) [PDF]

Journal of the Serbian Chemical Society, 2005
The stability constants of the 1:1 binary complexes of Ni(II) and Co(II) with 3-amino-1,2,4-triazole (AT), leucine (Leu) and glutamic acid (Glu), and the 1:1:1 ternary complex of them and the protonation constants of the ligands were determined ...
AYSE ERÇAĞ, TUBA SISMANOĞLU, SÜHEYLA PURA   +2 more
doaj  

Nitrogen and carbon limitation of planktonic primary production and phytoplankton–bacterioplankton coupling in ponds on the McMurdo Ice Shelf, Antarctica

Environmental Research Letters, 2013
We compared planktonic primary and secondary production across twenty meltwater ponds on the surface of the McMurdo Ice Shelf in January 2007, including some ponds with basal brines created by meromictic stratification.
Brian K Sorrell, Ian Hawes, Karl Safi
doaj   +1 more source

Branched chain aldehydes: production and breakdown pathways and relevance for flavour in foods [PDF]

, 2009
Branched aldehydes, such as 2-methyl propanal and 2- and 3-methyl butanal, are important flavour compounds in many food products, both fermented and non-fermented (heat-treated) products. The production and degradation of these aldehydes from amino acids
Engels, W.J.M., Smit, B.A., Smit, G.
core   +2 more sources

Cognitive and Patient‐Reported Outcome Measures in LGI‐1‐IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical outcome measures for autoimmune encephalitis (AE) are not yet well defined. Cognitive outcome measures (CogOs) and patient‐reported outcomes (PROs) may capture the symptoms of AE, beyond clinician‐reported outcomes (ClinROs) (the Modified Rankin Scale [mRS] and Clinical Assessment Scale in Autoimmune Encephalitis [CASE ...
Tatchaporn Ongphichetmetha, Carol Swetlik, Nicolas Thompson, Albert Aboseif, Vineet Punia, Brittany Lapin, Jeffrey A. Cohen, Rachel Galioto, Amy Kunchok   +8 more
wiley   +1 more source

Maillard Type Reaction for Electroless Copper Plating onto Ceramic Nanoparticles

Advanced Engineering Materials, EarlyView.
This work presents the manufacturing of copper‐plated ceramic nanoparticles in an environmentally friendly way. Supported by organic functionalizations with pectin an electroless plating step can be performed. Sustainable reagents like xylose, and several amino acids are used for the reduction process.
Lukas Mielewczyk, Julia Grothe, Stefan Kaskel, Heinrich von Lintel, Katja Eichmann, Katrin Jahns, Avinash Hariharan, Abdelrahman Elsayed, Ulrich Krupp   +8 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

The response of weaned piglets to dietary valine and leucine

Animal, 2017
Valine (Val) is considered to be the fifth-limiting amino acid in a maize–soyabean meal diet for pigs. Excess leucine (Leu) levels often occur in commercial diets, which may attenuate the effect of Val deficiency because of an increased oxidation of Val.
F. Meyer, C. Jansen van Rensburg, R.M. Gous   +2 more
doaj  

Sonochemical Functionalization of Glass

Advanced Functional Materials, EarlyView.
A new method for functionalizing glass using ultrasonication of aryl diazonium salts. Aryl radicals generated by ultrasounds react with glass, forming a stable, covalently bonded organic film. The functionalized glass adheres microorganisms such as microalgae, fungi, and bacteria, suggesting potential applications in enzyme production, filtration ...
Tiexin Li, Zane Datson, Sufia Hena, Steven Chang, Shane Werry, Leqi Zhao, Nasim Amiralian, Tejas Bhatelia, Francisco J. Lopez‐Ruiz, Melanie MacGregor, K. Swaminathan Iyer, Simone Ciampi, Muhammad J. A. Shiddiky, Nadim Darwish   +13 more
wiley   +1 more source

Genomic evidence for genes encoding leucine-rich repeat receptors linked to resistance against the eukaryotic extra- and intracellular Brassica napus pathogens Leptosphaeria maculans and Plasmodiophora brassicae [PDF]

, 2018
© 2018 Stotz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fitt, Bruce, Hossein, Borhan, Kukol, Andreas, Larkan, Nicholas, Mashanova, Alla, Parham, Haddadi, Pascoe, Harvey, Stotz, Henrik   +7 more
core   +3 more sources