Results 101 to 110 of about 355,417 (306)

Leucine-Specific, Functional Interactions between Human Immunodeficiency Virus Type 1 Nef and Adaptor Protein Complexes

, 2005
The human immunodeficiency virus type 1 virulence protein Nef interacts with the endosomal sorting machinery via a leucine-based motif. Similar sequences within the cytoplasmic domains of cellular transmembrane proteins bind to the adaptor protein (AP ...
Douglas Hitchin, Hitchin, Douglas, John R. Day, Serge Benichou, Van Damme, Nanette, Benichou, Serge, John C. Guatelli, Ricardo Madrid, Guatelli, John, Colleen M. Noviello, Scott H. Coleman, Madrid González, Ricardo, Day, John, Noviello, Colleen, Nanette Van Damme, Coleman, Scott   +15 more
core   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Leucine 2,3-aminomutase, an enzyme of leucine catabolism.

Journal of Biological Chemistry, 1976
The initial step in the fermentation of leucine to acetate, isobutyrate, and ammonia by Clostridium sporogenes is the B12 coenzyme-dependent conversion of alpha-leucine to beta-leucine (3-amino-4-methylpentanoate). The amino group migration reaction, catalyzed by leucine 2,3-aminomutase, is reversible and is inhibited by intrinsic factor.
openaire   +2 more sources

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Leucine transport in platelets.

Haematologica, 1980
[No abstract available]
OZBILEN, A, YARDIMCI, TU, ULUTIN, ON
openaire   +2 more sources

Whole body leucine turnover.

, 2013
Whole body leucine rate of appearance (Ra), leucine oxidation, and non-oxidative leucine rate of disappearance (Rd) [µmol⋅kg−1⋅min−1] in male subjects at sea level and after 7–9 days exposure to high altitude. N = 6, and values are mean ± SEM.
Bengt Saltin (358765), Lars Holm (358762), Mads Lyhne Haslund (358763), Jose A. L. Calbet (52755), Carsten Lundby (52760), Gerrit van Hall (358764), Paul Robach (52754)   +6 more
core   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Effect of Polyphenol-Rich Diet Combined with Leucine, Vitamin D3, and Magnesium Supplementation on Self-Reported Mobility and Health Perception in Adults at Risk of Sarcopenia: A 3-Months Quasi-Experimental Study

Life
Background: Sarcopenia is characterized by progressive muscle weakness, impaired physical function, and reduced quality of life. Multimodal strategies combining rehabilitation and nutritional support that influence gut microbiota may help improve ...
Diana-Lidia Tache-Codreanu, Ana-Maria Tache-Codreanu, Georgeta Stefan, Magdalena Rodica Trăistaru, Elena Rusu, Andrei Tache-Codreanu, Corina Sporea   +6 more
doaj   +1 more source

Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects

, 2013
Michael B Zemel,1,2 Antje Bruckbauer11NuSirt Sciences Inc, 2Nutrition Department, The University of Tennessee, Knoxville, TN, USABackground: We recently demonstrated leucine to modulate energy partitioning between adipose tissue and muscle.
Bruckbauer A, Zemel MB
core