Results 121 to 130 of about 355,417 (306)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Cellular processes associated with LRRK2 function and dysfunction.

, 2015
Mutations in the leucine-rich repeat kinase 2 (LRRK2) encoding gene are the most common cause of monogenic Parkinson's Disease (PD). The identification of LRRK2 polymorphisms associated with increased risk for sporadic PD, as well as the observation that
Manzoni, C, Bandopadhyay, R, Wallings, R
core  

Effects of leucine on whole body leucine, valine, and threonine metabolism in humans

, 1997
We tested whether expansion of the plasma leucine pool distorts leucine or valine tracer kinetics, causing errors in the derived values of whole body proteolysis.
O. A. Mamer, L. J. Hoffer, M. J. Hamadeh, A. Taveroff, L. Robitaille   +4 more
core   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, EarlyView.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Covariance analysis of L-[1-11C]leucine PET: methodological considerations

openProtein biosynthesis in the central nervous system (CNS) is essential for physiological maintenance and neural circuitry function, thus serving as a translational biomarker for behavioral, adaptive and cognitive processes.
FIORITI, GIADA
core  

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Effects of dietary carbohydrate and energy intake on LAT1 protein expression in rat skeletal muscle

Journal of Physical Fitness and Sports Medicine
Glucose has been reported to reduce the expression of L-type amino acid transporter 1 (LAT1) protein in C2C12 myocytes. We therefore hypothesized that increased dietary carbohydrate and energy intake would reduce LAT1 protein expression in rodent ...
Aki Yokogawa, Keigo Tanaka, Ikuru Miura, Shinya Watanabe, Yusuke Iwao, Daisuke Takakura, Tongzhu Zhou, Kohei Kido, Kentaro Kawanaka   +8 more
doaj   +1 more source

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source