Results 151 to 160 of about 285,613 (247)

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Branched-Chain Amino Acids in Parkinson's Disease: Molecular Mechanisms and Therapeutic Potential. [PDF]

Int J Mol Sci
Huang HY, Tsao SP, Yeh TH.
europepmc   +1 more source

Syntheses of 3,3-Dimethyl-2-hydroxybutyric Acid and Tertiary Leucine and Their Optical Resolutions [PDF]

, 1968
Tadashi Tanabe, Shinichi Yajima, Masami Imaida   +2 more
openalex   +1 more source

Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling

Advanced Science, EarlyView.
Polycystin‐1 (PC1) senses collagen and ECM stiffness to promote tumor migration via Daam1‐mediated actin remodeling. A cleavage‐resistant PC1 mutant enhances YAP nuclear translocation and CTGF expression, which activates CAFs and further stiffens the ECM, forming a feed‐forward loop that drives tumor progression and metastasis.
Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu   +12 more
wiley   +1 more source

Leucine-rich alpha-2 glycoprotein expression in gingival tissues with chronic periodontitis. [PDF]

Bioinformation
Badipati RB, Chintalapani S, Usha P, Tummakomma P, Arya A, Muttineni N, Rajaram H.   +6 more
europepmc   +1 more source

A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics

Advanced Science, EarlyView.
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie, Jiaxin Han, Xingyi Dai, Xuyang Zhang, Kangwen Xiao, Junhui Huang, Yajun Cao, Aihua Zhong, Long‐Biao Huang   +8 more
wiley   +1 more source

Amino Acid-Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis. [PDF]

Adv Sci (Weinh)
Luo P, Tong K, Gan Y, Tang M, Niu Y, Liu K, Ni S, Wu S, Jiang X, Jiang H, Xiao F, Chen S, Lv W, Li X, Yuan F, Guo F.   +15 more
europepmc   +1 more source

Restoration of Lost Virulence of Leucine- Requiring Mutants of Xanthomonas oryzae by DNA-Mediated Transformation

, 1966
Yoshito Yamasaki, Nobuo Murata, Takashi Suwa   +2 more
openalex   +2 more sources

A Versatile Near‐Infrared Fluorescent Probe for Fast Assessment of Lysosomal Status via a Large Multimodal Model

Aggregate, EarlyView.
Herein, we report a quinolinium‐based fluorescent probe, PA‐2, for near‐infrared super‐resolution imaging of lysosomal dynamics. Building on this, we next introduce a novel approach leveraging a large multimodal model (LMM), an advanced artificial intelligence tool, for automated image interpretation.
Rui Chen, Eugene Lee, Yuxin Wang, Aditya Yadav, Minling Zhong, Pragti, Yujie Sun, Jiajie Diao   +7 more
wiley   +1 more source

Enzymatic Racemization of Leucine and α-Aminobutyrate

, 1969
Takaharu OSUMI, Tatsuo Yamamoto, Kenji Soda   +2 more
openalex   +2 more sources