Results 161 to 170 of about 545,233 (335)
Advanced Science, EarlyView.This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang +19 more
wiley +1 more source
The Genetic Wiring of Plant Trichomes: From Initiation to Fate Specification
Advanced Science, EarlyView.Plant trichomes are not just simple hairs but metabolic powerhouses shaped by complex genetic programs. While the MYB‐bHLH‐WD40 module is well studied in Arabidopsis, recent findings reveal that HD‐Zip IV transcription factors drive multicellular and glandular trichome development through dose‐dependent mechanisms.
Meng Li +3 more
wiley +1 more source
Leucine-Sensitive Hypoglycæmia [PDF]
Proceedings of the Royal Society of Medicine, 1970 G, Tevaarwerk +3 more
openaire +2 more sources
Advanced Science, EarlyView.The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang +22 more
wiley +1 more source
Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
wiley +1 more source