Results 191 to 200 of about 603,709 (398)

Leucine-Sensitive Hypoglycæmia [PDF]

open access: yesProceedings of the Royal Society of Medicine, 1964
C Harmer, L Sinclair, H M T Coles
openaire   +3 more sources

Effects of Dictyophora polysaccharide on cerebellar Purkinje cell degeneration in a chronic alcohol mouse model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang   +5 more
wiley   +1 more source

Protein Secondary Structure Patterns in Short‐Range Cross‐Link Atlas

open access: yesAngewandte Chemie, EarlyView.
Short‐range cross‐linking mass spectrometry (XL‐MS) reveals secondary structure‐dependent patterns in proteome‐wide datasets. By integrating XL‐MS data with AlphaFold‐predicted structures, we introduce X‐SPAN, a novel validation metric that assesses data quality and enables pLDDT score benchmarking.
Alice Vetrano   +6 more
wiley   +2 more sources

A Comparison of Leucine- and Acetoacetate-induced Hypoglycemia in Man* [PDF]

open access: bronze, 1964
Stefan S. Fajans   +3 more
openalex   +1 more source

Research advances in dysphagia animal models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai   +5 more
wiley   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

open access: yesAnnals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel   +10 more
wiley   +1 more source

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