Results 61 to 70 of about 639,233 (341)
The L-amino acid oxidase of Neurospora [PDF]
, 1951 In 1944 one of us described a D-amino acid oxidase in extracts of Neurospora crassa (1). Except for slight activity against L-glutamate, no oxidation of L-amino acids was observed.
Horowitz, N. H., Thayer, Philip S.
core +1 more source
Differential regulation of mTORC1 by leucine and glutamine
Science, 2015 Getting specific about amino acid sensing The protein kinase complex mTORC1 regulates growth and metabolism, and its activity is controlled in response to the abundance of cellular amino acids. Jewell et al.
Jenna L. Jewell +7 more
semanticscholar +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Intermolecular hydrogen bonding of the two independent molecules of N-3,5-dinitrobenzoyl-L-leucine [PDF]
, 2000 The title compound, C₁₃H₁₅N₃O₇, crystallizes as two independent molecules which differ in their conformation. Intermolecular hydrogen bonding between the amide and carboxylic acid groups as N-H...O=C interactions results in the formation of one ...
Gallagher, John F. +2 more
core +1 more source
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1
Science, 2019 A tRNA synthase in metabolic control Leucyl-tRNA synthetase 1 (LARS1), which covalently couples leucine to its cognate transfer RNAs (tRNAs), appears to have broader roles in the control of leucine metabolism.
Ina Yoon +23 more
semanticscholar +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2020 Leucine, an essential branched amino acid, has anti-obesity effects on glucose tolerance, lipid metabolism, and insulin sensitivity. The catabolism of Leucine is a conserved regulator of physiological aging, participating in diverse physiological and pathological processes. This topic review offers an up-to-date report on the decomposition and
openaire +1 more source
The uptake in vitro of C14-labeled glycine, L-leucine, and L-lysine by different components of guinea pig liver homogenate [PDF]
, 1950 We have reported (1) that L-lysine labeled with C14 can be incorporated into the proteins of guinea pig liver homogenate under two different conditions.
Borsook, Henry +4 more
core
American Journal of Physiology. Endocrinology and Metabolism, 2019 Previous studies established that leucine stimulates protein synthesis in skeletal muscle to the same extent as a complete mixture of amino acids, and the effect occurs through activation of the mechanistic target of rapamycin in complex 1 (mTORC1 ...
Dandan Xu +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source