Results 71 to 80 of about 285,613 (247)

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

open access: yesAdvanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang   +6 more
wiley   +1 more source

THE SPECIFICITY OF LEUCINE AMINOPEPTIDASE

open access: hybrid, 1949
Emil L. Smith, W. J. Polglase
openalex   +1 more source

Isovaleric acidemia: a new genetic defect of leucine metabolism. [PDF]

open access: bronze, 1966
Kay Tanaka   +3 more
openalex   +1 more source

Leucine-Sensitive Hypoglycæmia [PDF]

open access: yesProceedings of the Royal Society of Medicine, 1964
C Harmer, L Sinclair, H M T Coles
openaire   +3 more sources

The Probiotic Parabacteroides johnsonii Ameliorates Metabolic Disorders Through Promoting BCAAs to BSCFAs Conversion

open access: yesAdvanced Science, EarlyView.
Clinical discovery and the proposed underlying mechanism by how P. johnsonii ameliorated metabolic disorders. Abstract The gut bacterium Parabacteroides spp. is increasingly recognized for its therapeutic potential in treating metabolic disorders. However, the role of Parabacteroides johnsonii in metabolic disorders is never reported.
Yimeng Chen   +9 more
wiley   +1 more source

A Blast‐Resistant NLR Gene Confers Drought Resistance by Competitively Interacting with an E3 Ligase to Protect Phenylalanine Ammonia‐Lyase in Rice

open access: yesAdvanced Science, EarlyView.
The NLR protein PibH8 interacts with phenylalanine ammonia‐lyase OsPAL1 and E3 ubiquitin ligase OsFBK16. Through competitive binding, PibH8 weakens the interaction between OsFBK16 and OsPAL1, thereby reducing the degradation of OsPAL1 by OsFBK16. The Hap1 allele of PibH8 exhibits a higher expression level than Hap2, thus accumulating more PibH8 protein,
Denghao Xiang   +17 more
wiley   +1 more source

Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition

open access: yesAdvanced Science, EarlyView.
Phytophthora capsici effector PcRD18 targets tomato GSNOR to disrupt NO homeostasis, promoting S‐nitrosylation of immune proteins like RBOHD. This suppresses ROS bursts and promotes pathogen infection. Mutation of the PcRD18‐binding sites of GSNOR avoids pathogen manipulation and offers a strategy to enhance crop resistance. Abstract Nitric oxide (NO),
Tingting Li   +8 more
wiley   +1 more source

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