Results 141 to 150 of about 23,013 (189)

Leucovorin-induced hypersensitivity reaction

Journal of Oncology Pharmacy Practice, 2011
Leucovorin is a reduced form of folic acid, which has multiple uses. 1 In this case report, it is used in combination with fluorouracil in the treatment of colon cancer. We describe a 53-year-old male, who was started on FOLFOX 6 + bevacizumab who experienced a hypersensitivity reaction to ...
Avni, Damaske, Nichole, Ma, Reba, Williams   +2 more
openaire   +2 more sources

Experience with 5FU + L-Leucovorin

1993
The mainstay of treatment for patients with metastatic colorectal cancer is chemotherapy with the combination of 5-Fluorouracil (5FU) and Leucovorin (LV) 1. This treatment has resulted in a response rate of 23% compared to 11% for 5FU in nine randomized trials of patients with previously untreated metastatic colorectal cancer 2.
C, Erlichman, S, Fine, I, Kerr, W, Hoffman, C, Gorg, H J, Schmoll, P, Preusser, H J, Senn, B, Gustavsson   +8 more
openaire   +2 more sources

Pharmacodynamics of 5-Fluorouracil and Leucovorin

1988
Fluoropyrimidine therapy is a corner-stone of chemotherapeutic management of metastatic cancer. Although only about 15% of patients respond to initial single-agent FUra therapy, a greater number may have disease stabilization with comparatively mild toxicity1,2.
B G, Gustavsson, G, Carlsson, R, Frösing, C P, Spears   +3 more
openaire   +2 more sources

Metabolic pathway for leucovorin

Molecular Diagnosis, 2000
  +5 more sources

Chemistry of Leucovorin

Journal of the American Chemical Society, 1952
Donna Cosulich, Barbara Roth, James Smith, Jr., Martin Hultquist, Robert Parker   +4 more
openaire   +2 more sources

UFT/leucovorin vs 5-FU/leucovorin in colon cancer.

Oncology (Williston Park, N.Y.), 2001
Adjuvant chemotherapy has been shown to alter the natural history of resected colon cancer. Two regimens (fluorouracil [5-FU] plus leucovorin and 5-FU plus levamisole) have been found to prolong disease-free survival and overall survival in affected patients.
R E, Smith, B C, Lembersky, H S, Wieand, L, Colangelo, E P, Mamounas   +4 more
openaire   +1 more source

Leucovorin Calcium

2022
Michelle C. Simpson, Eric G. Schaefer
openaire   +1 more source

Leucovorin Calcium

2021
openaire   +2 more sources

Leucovorin modulation of fluorouracil.

Oncology (Williston Park, N.Y.), 1993
Fluorouracil remains the single most active chemotherapy agent in colorectal cancer. One of its principal mechanisms of action is inhibition of the enzyme thymidylate synthase (TS), a central enzymatic step in de novo pyrimidine synthesis. Leucovorin, which is metabolized intracellularly to polyglutamated 5,10-methylenetetrahydrofolate, modulates the ...
L, Grogan, G A, Sotos, C J, Allegra
openaire   +1 more source

Leucovorin.

2011
openaire   +2 more sources