Results 131 to 140 of about 23,013 (189)

Real-World Outcomes of Peri-Operative Chemotherapy With Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel in Upper Gastrointestinal Cancers: An Audit of Patients Diagnosed Between 2017 and 2020 at the Christie Hospital.

Cureus
Sabry M, Mahmoud Y, Hatahet Y, Patel R, Ibrahim N.   +4 more
europepmc   +1 more source

Metabolomics and proteomics analyses reveal the potiental mechanisms underlying colorectal cancer and chemotherapy targets. [PDF]

BMC Cancer
Li Q, Chen Q, Chang J, Fu T, Xiao T, Chen J, Yang T.   +6 more
europepmc   +1 more source

Case Report: long complete metabolic response assessed by LAFOV FDG-PET/CT to FOLFIRINOX in first-line treatment of metastatic low-differentiated pancreatic carcinoma. [PDF]

Front Med (Lausanne)
Abgral R, Dzuko Kamga J, Metges JP, Salaun PY.   +3 more
europepmc   +1 more source

NALIRIFOX versus gemcitabine plus nab-paclitaxel in Chinese patients with advanced pancreatic adenocarcinoma: a randomized, open-label phase II trial. [PDF]

Nat Commun
Gao C, Zhang Y, Qu X, Chen X, Zhang J, Wu H, Sun M, Zha Y, Wang J, Wang Y, Li Z, Gao J, Lin R, Zang A, Zhang H, Yuan X, Du C, Zhao J, Yang Y, Shi X, Cheng W, Wang B, Wu S, Zhao T, Wang J, Gao S, Wang X, Ma W, Liu R, Shi Y, Liu Y, Xie Y, Niu M, Zhao F, Yu J, Hao J.   +35 more
europepmc   +1 more source

Body mass index has no impact on complications and mortality for patients with stage IV pancreatic ductal adenocarcinoma. [PDF]

Transl Gastroenterol Hepatol
Bryant R, Darnell H, Hall M, Karnik K, McQuerry K, Plentz RR.   +5 more
europepmc   +1 more source

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Pharmacokinetic comparison of leucovorin and levoleucovorin

European Journal of Clinical Pharmacology, 1993
The pharmacokinetic values of d,l-leucovorin and l-leucovorin were compared in eight healthy volunteers following oral administration of 25 mg d,l-leucovorin and 12.5 mg l-leucovorin. Serum levels of l-5-formyltetrahydrofolate, l-5-methyltetrahydrofolate, and total reduced folates were measured by an established microbiological method.
Avraham Yacobi, J Marquet
exaly   +3 more sources

Leucovorin as a Prodrug

1993
To exert its antitumor effects, leucovorin must ultimately become activated by conversion to CH2FH4.* Elevation of this reduced folate cofactor stabilizes the inhibitory ternary complex formed between the FU active metabolite, FdUMP and thymidylate synthase, resulting in suppression of DNA synthesis or repair.1–4 It has been demonstrated both in animal
D G, Priest, J C, Schmitz, T, Walle
openaire   +2 more sources

The metabolic role of leucovorin

Trends in Biochemical Sciences, 1993
Interest in determining if leucovorin, known chemically as 5-formyltetra-hydrofolate, plays a role in one-carbon metabolism is reemerging. While investigations in the 1940s suggested it was an important donor of one-carbon units in folate-mediated biosynthetic reactions, studies between the 1950s and 1980s disproved this hypothesis and dismissed its ...
P, Stover, V, Schirch
openaire   +2 more sources