Results 181 to 190 of about 40,253 (233)
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The metabolic role of leucovorin
Trends in Biochemical Sciences, 1993Interest in determining if leucovorin, known chemically as 5-formyltetra-hydrofolate, plays a role in one-carbon metabolism is reemerging. While investigations in the 1940s suggested it was an important donor of one-carbon units in folate-mediated biosynthetic reactions, studies between the 1950s and 1980s disproved this hypothesis and dismissed its ...
P, Stover, V, Schirch
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Experience with 5FU + L-Leucovorin
1993The mainstay of treatment for patients with metastatic colorectal cancer is chemotherapy with the combination of 5-Fluorouracil (5FU) and Leucovorin (LV) 1. This treatment has resulted in a response rate of 23% compared to 11% for 5FU in nine randomized trials of patients with previously untreated metastatic colorectal cancer 2.
C, Erlichman +8 more
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UFT/leucovorin vs 5-FU/leucovorin in colon cancer.
Oncology (Williston Park, N.Y.), 2001Adjuvant chemotherapy has been shown to alter the natural history of resected colon cancer. Two regimens (fluorouracil [5-FU] plus leucovorin and 5-FU plus levamisole) have been found to prolong disease-free survival and overall survival in affected patients.
R E, Smith +4 more
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Leucovorin modulation of fluorouracil.
Oncology (Williston Park, N.Y.), 1993Fluorouracil remains the single most active chemotherapy agent in colorectal cancer. One of its principal mechanisms of action is inhibition of the enzyme thymidylate synthase (TS), a central enzymatic step in de novo pyrimidine synthesis. Leucovorin, which is metabolized intracellularly to polyglutamated 5,10-methylenetetrahydrofolate, modulates the ...
L, Grogan, G A, Sotos, C J, Allegra
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