Results 71 to 80 of about 40,253 (233)

Open Versus Hybrid and Total Minimally Invasive Transthoracic Ivor Lewis Esophagectomy Following Neoadjuvant FLOT Chemotherapy: An Australian and New Zealand Cohort Study

World Journal of Surgery, EarlyView.
Retrospective analysis of transthoracic oesophagectomies undertaken between 2017 and 2022 following neoadjuvant FLOT chemotherapy from 22 ANZ centers. The primary endpoint was the rate of major (Clavien‐Dindo grade ≥ 3) postoperative complication.
Brendan Desmond, Maneesha De Silva, Darren J. Wong, David I. Watson, Cuong P. Duong, Tim Bright, Ahmad Aly, Margaret Lee, Kevin Chan, Garett Smith, David L. Chan, Neil Merrett, Sivakumar Gananadha, Yick Ho Lam, Harsh Kanhere, Mark Smithers, Michael Bozin, Matthew Read, Krinal Mori, Mary‐Ann Johnson, Enoch Wong, Sarah A. Martin, Geraldine Ooi, Yahya Al‐Habbal, Chon Hann Liew, Robert Bohmer, Jurstine Daruwalla, Mo Ballal, Rukshan Ranjan, Andrew D. MacCormick, Sharon Pattison, Nicholas Evennett, Jason Robertson, James Tan, Alexandra Gordon, Simon Bann, David S. Liu, SPACE‐FLOT ANZ Investigators   +37 more
wiley   +1 more source

Mucocutaneous Ulcerations and Pancytopenia Secondary to Methotrexate Toxicity in a Patient With Rheumatoid Arthritis: A Case Report

Clinical Case Reports
Toxicity from methotrexate overdosing is life threatening condition that requires prompt recognition and early treatment. A 71‐year‐old man from rural Bhutan with diabetes mellitus had symmetrical small joint pain for 3 years associated with early ...
Thinley Dorji, Tshering Penjor, Sangay Tenzin, Tshering Pedon, Sangay Wangchuck, Sonam Yangchen   +5 more
doaj   +1 more source

Irinotecan Hydrochloride (CPT-11) in Dialysis Patients with Gastrointestinal Cancer [PDF]

, 2010
We investigated changes in drug disposition and toxicities with CPT-11 in 15 dialysis patients with gastrointestinal cancers to clarify whether CPT-11 could be administered safely in such patients.
Akashi, Isao, Ashizawa, Tatsuto, Hama, Kouichirou, Hirano, Toshihiko, Iwahori, Tohru, Iwamoto, Hitoshi, Jyojima, Yoshimaro, Kihara, Yuu, Konnno, Osamu, Nagao, Takeshi, Nakamura, Yuuki, Segawa, Mai, Takeuchi, Hironori, Yokoyama, Takayoshi   +13 more
core   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Two Decades of Multimodal Management of Colorectal Liver Metastases With Long‐Term Outcomes

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The management of patients with colorectal liver metastases (CRLM) is complex and requires a tailored approach based on disease extent, patient age, and comorbidities. Given the heterogeneity in presentation and evolving treatment algorithms, prognostic factors for long‐term survival following liver resection are contested.
Ali Mohtashami, Prajwol Shrestha, Sharon Chen, Jean‐Luc Vrisakis, Nazim Bhimani, Nick Pavlakis, Stephen J. Clarke, Connie I. Diakos, Matthew Wong, Thomas J. Hugh   +9 more
wiley   +1 more source

Acute methotrexate toxicity managed with leucovorin and pegylated granulocyte colony-stimulating factor: A report of two cases and review of literature

Clinical Dermatology Review
Acute methotrexate (MTX) toxicity is most commonly due to overdose of the drug, which may be due to the patient's noncompliance to doctor's orders or physician's prescription error. Other causes include acute renal failure, concomitant use of other drugs,
Shiva Shankar Marri, Mohnish Sekar, Keshavmurthy A Adya, Arun C Inamadar, Ajit B Janagond   +4 more
doaj   +1 more source

Role of gemcitabine in the treatment of advanced and metastatic breast cancer [PDF]

, 2003
Gemcitabine is an antimetabolite drug with proven antitumor activity and tolerability in metastatic breast cancer. In a total of nine studies, gemcitabine monotherapy has reached response rates of up to 37% in the first-line setting, 26% in the second ...
Heinemann, Volker
core   +1 more source

Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2‐p53 Pathway and M2 Macrophage Polarization

Cancer Science, EarlyView.
SLC1A3 promotes colorectal cancer progression by transporting extracellular aspartate into tumor cells, thereby activating the PKC/MDM2/p53 pathway to enhance proliferation. Reduced extracellular aspartate, combined with p53‐dependent suppression of CSF2 and IL17C, drives M2 macrophage polarization via immune modulation, macrophage recruitment, and M2 ...
Chao Deng, You Zhou, Sijie Song, Hongtao Liu, Siqi Liao, Li Zhou, Siyuan Chen, Zhihang Zhou, Song He, Bingrong Liu   +9 more
wiley   +1 more source

Retrospective analysis of cases with low dose methotrexate-induced neutropenia

Ulusal Romatoloji Dergisi
Objective: Low dosemethotrexate (MTX) is among the most commonly used drugs in rheumatology and rarely associated with neutropenia. It is generally observed as a result of improper use or in patients with risk factors for toxicity.
Elif Dinçses Nas, Sevilay Batıbay
doaj   +1 more source

Folate pathway genes linked to mitochondrial biogenesis and respiration are associated with outcome of patients with stage III colorectal cancer

Tumor Biology, 2019
5-fluorouracil in combination with the folate leucovorin is the cornerstone in treatment of colorectal cancer. Transport of leucovorin into cells, and subsequent metabolic action, require expression of several genes.
Elisabeth Odin, Arvid Sondén, Göran Carlsson, Bengt Gustavsson, Yvonne Wettergren   +4 more
doaj   +1 more source