Results 51 to 60 of about 16,120 (166)
Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation
Environmental Microbiology, Volume 28, Issue 11, November 2026.Using targeted mutagenesis, this study shows that form II CODH does not contribute to CO oxidation in the model carboxydovore Paraburkholderia terrae COX and reveals that canonical maturation pathways are not universally conserved. These findings refine genome‐based predictions of microbial metabolism and improve understanding of metalloenzyme assembly
R. A. Dawson, M. Hernández
wiley +1 more source
A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei.
PLoS Pathogens, 2017 The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle.
Priscila Peña-Diaz +4 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 17, 14 September 2026.Evaluation of two libraries of peptoid‐based compounds for inhibitory activity against PfA‐M1 from Plasmodium falciparum, TcLAP from Trypanosoma cruzi, and LmLAP from Leishmania major reveals the crucial role of hydrophobic interactions in the inhibition process of these parasite metallo‐aminopeptidases.
Mirta Elisa Aguado +16 more
wiley +1 more source
TrpM, a Small Protein Modulating Tryptophan Biosynthesis and Morpho-Physiological Differentiation in Streptomyces coelicolor A3(2). [PDF]
PLoS ONE, 2016 In the model actinomycete Streptomyces coelicolor A3(2), small open reading frames encoding proteins with unknown functions were identified in several amino acid biosynthetic gene operons, such as SCO2038 (trpX) in the tryptophan trpCXBA locus.
Emilia Palazzotto +9 more
doaj +1 more source
Extracellular peptidase and carbohydrate hydrolase activities in an Arctic fjord (Smeerenburgfjord, Svalbard) [PDF]
, 2013 Measurements of the spectrum of extracellular enzymes present in an environment can indicate the nature of organic substrates available to microorganisms.
Steen, Andrew D., Arnosti, Carol
core +1 more source
Experimental Evidence for a Metallohydrolase Mechanism in Which the Nucleophile Is Not Delivered by a Metal Ion: EPR Spectrokinetic and Structural Studies of Aminopeptidase from \u3cem\u3eVibrio proteolyticus\u3c/em\u3e [PDF]
, 2007 Metallohydrolases catalyse some of the most important reactions in biology and are targets for numerous chemotherapeutic agents designed to combat bacterial infectivity, antibiotic resistance, HIV infectivity, tumour growth, angiogenesis and immune ...
Bennett, Brian +4 more
core
The identity of cysteine proteinases and their distribution within several major coleopteran families. [PDF]
, 1991 Based on the hydrolysis of synthetic substrates, pH optima for substrate hydrolysis and effects of potential activators and inhibitors, the identity and occurrence of cysteine proteinases in several major coleopteran families were investigated.
Thie, Norman Michael Reinhold.
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Scientific Reports, 2022 Imbalanced glucose tolerance and insulin resistance remain important as high cancer risk factors. Metformin administration to diabetic patients may be associated with a reduced risk of malignancy.
Natalia Kurhaluk, Halyna Tkachenko
doaj +1 more source
Functional Ecology, Volume 40, Issue 5, Page 1415-1427, May 2026.Read the free Plain Language Summary for this article on the Journal blog. Abstract Wildfires are disrupting and regenerating forces in nature that affect all ecosystem components. However, the impact of wildfires on soil multitrophic biodiversity and the resulting consequences for ecosystem multifunctionality (EMF) remain poorly understood.
Juan Zhou +6 more
wiley +1 more source
, 2019 Drug-induced liver injury (DILI) is a frequent cause of hepatic dysfunction as well as the single most frequent reason for removing approved medications from the market, and multispectral optoacoustic tomography (MSOT) is an emerging and noninvasive ...
Yong Huang +9 more
core +1 more source