Results 61 to 70 of about 1,860 (145)

Brugia malayi excreted/secreted proteins at the host/parasite interface: stage- and gender-specific proteomic profiling.

PLoS Neglected Tropical Diseases, 2009
Relatively little is known about the filarial proteins that interact with the human host. Although the filarial genome has recently been completed, protein profiles have been limited to only a few recombinants or purified proteins of interest.
Sasisekhar Bennuru, Roshanak Semnani, Zhaojing Meng, Jose M C Ribeiro, Timothy D Veenstra, Thomas B Nutman   +5 more
doaj   +1 more source

Variations in eco-enzymatic stoichiometric and microbial characteristics in paddy soil as affected by long-term integrated organic-inorganic fertilization.

PLoS ONE, 2017
To investigate the effects of different nutrient management regimes on the soil chemical, eco-enzymatic stoichiometric and microbial characteristics, soil samples were collected from a 30-year, long-term field experiment with six plots growing rice.
Sen Lin, Shaoxian Wang, Yuanli Si, Wenhao Yang, Shaowei Zhu, Wuzhong Ni   +5 more
doaj   +1 more source

Role of β-glucans in reducing oxidative stress and improving muscle tissue health in European whitefish (Coregonus lavaretus L.)

Fisheries & Aquatic Life
β-glucans are currently a notable topic in research on enhancing immunity in fishes and their significant role in improving fish health and productivity in aquaculture.
Tkaczenko Halina, Grudniewska Joanna, Kurhaluk Natalia   +2 more
doaj   +1 more source

Aminopeptidases in Mycelium and Growth Medium of Streptomyces rimosus Strains

Food Technology and Biotechnology, 2009
Aminopeptidases (APs) of the same substrate specificities have been detected in the mycelia and culture filtrate of Streptomyces rimosus. To compare extracellular and intracellular prolyl, leucyl and arginyl AP, dynamics of their biosynthesis, excretion ...
Jasminka Špoljarić, Bojana Vukelić, Ljubinka Vitale   +2 more
doaj  

Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin. [PDF]

The Journal of biological chemistry, 2006
Malaria aminopeptidases are important in the generation and regulation of free amino acids that are used in protein anabolism and for maintaining osmotic stability within the infected erythrocyte. The intraerythrocytic development of malaria parasites is blocked when the activity of aminopeptidases is specifically inhibited by reagents such as bestatin.
Gardiner, Donald L., Trenholme, Katharine R., Skinner-Adams, Tina S., Stack, Colin M., Dalton, John P.   +4 more
openaire   +3 more sources

Expression, Characterisation, Homology Modelling and Molecular Docking of a Novel M17 Family Leucyl-Aminopeptidase from Bacillus cereus CZ. [PDF]

Int J Mol Sci, 2023
Liu J, Cui T.
europepmc   +1 more source

Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity.

PLoS Neglected Tropical Diseases
BackgroundChagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy.
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker   +16 more
doaj   +1 more source

Ubenimex synergizes with the PD-L1 blockade in gastric cancer by competitively binding LAP3 with UBE3A

Cell Death and Disease
Immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 blockade, represent a cornerstone of treatment for advanced gastric cancer (GC). However, their clinical efficacy is hampered by low response rates and the development of both primary and ...
Caixia Zhao, Jiaxin Li, Jinxiu Zheng, Ming Chi, Ying Shao, Yuxin Che, Wenjing Chen, Jie Dai, Chunxia Chen, Xiaoning Li, Likun Zan, Yu Shi, Yujing Duan, Lijun Yang, Tao Yang   +14 more
doaj   +1 more source

Overexpression of Leucyl Aminopeptidase in Plasmodium falciparum Parasites [PDF]

Journal of Biological Chemistry, 2006
Donald L. Gardiner, Katharine R. Trenholme, Tina S. Skinner-Adams, Colin M. Stack, John P. Dalton   +4 more
openaire   +1 more source

Genome-wide mapping of the binding sites of myocyte enhancer factor 2A in chicken primary myoblasts

Poultry Science
: Myocyte enhancer factor 2A (MEF2A) is a transcription factor that plays a critical role in cell proliferation, differentiation and apoptosis. In contrast to the wide characterization of its regulation mechanism in mammalian skeletal muscle, its role in
Xinglong Wang, Jiannan Zhang, Jiancheng Su, Tianjiao Huang, Ling Lian, Qinghua Nie, Xin Zhang, Juan Li, Yajun Wang   +8 more
doaj   +1 more source