Results 61 to 70 of about 3,849 (186)

A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei.

PLoS Pathogens, 2017
The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle.
Priscila Peña-Diaz, Marie Vancová, Christian Resl, Mark C Field, Julius Lukeš   +4 more
doaj   +1 more source

Effects of melatonin and metformin in preventing lysosome-induced autophagy and oxidative stress in rat models of carcinogenesis and the impact of high-fat diet

Scientific Reports, 2022
Imbalanced glucose tolerance and insulin resistance remain important as high cancer risk factors. Metformin administration to diabetic patients may be associated with a reduced risk of malignancy.
Natalia Kurhaluk, Halyna Tkachenko
doaj   +1 more source

Structural Basis for Catalysis by the Mono- and Dimetalated Forms of the \u3cem\u3edapE\u3c/em\u3e-Encoded \u3cem\u3eN\u3c/em\u3e-succinyl-L,L-Diaminopimelic Acid Desuccinylase [PDF]

, 2010
Biosynthesis of lysine and meso-diaminopimelic acid in bacteria provides essential components for protein synthesis and construction of the bacterial peptidoglycan cell wall. The dapE operon enzymes synthesize both meso-diaminopimelic acid and lysine and,
Fan, Yao, Gillner, Danuta, Holz, Richard C., Joachimiak, Andzrej, Nocek, Boguslaw P.   +4 more
core   +1 more source

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

Unravelling potential virulence factor candidates in Xanthomonas citri. subsp. citri by secretome analysis [PDF]

PeerJ, 2016
Citrus canker is a major disease affecting citrus production in Brazil. It’s mainly caused by Xanthomonas citri subsp. citri strain 306 pathotype A (Xac).
Rafael M. Ferreira, Leandro M. Moreira, Jesus A. Ferro, Marcia R.R. Soares, Marcelo L. Laia, Alessandro M. Varani, Julio C.F. de Oliveira, Maria Ines T. Ferro   +7 more
doaj   +2 more sources

Inhibition of the Aminopeptidase from \u3cem\u3eAeromonas proteolytica\u3c/em\u3e by l-leucinethiol: Kinetic and Spectroscopic Characterization of a Slow, Tight-binding Inhibitor–enzyme Complex [PDF]

, 2000
The peptide inhibitor l-leucinethiol (LeuSH) was found to be a potent, slow-binding inhibitor of the aminopeptidase from Aeromonas proteolytica (AAP). The overall potency (KI*) of LeuSH was 7 nM while the corresponding alcohol l-leucinol (LeuOH) was a ...
Bennett, Brian, Bienvenue, David L., Holz, Richard C.   +2 more
core   +1 more source

Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases [PDF]

Arkivoc, 2012
The M1 alanyl aminopeptidase and M17 leucyl aminopeptidase are critical to the growth and development of malaria parasites inside host erythrocytes. Potent aminopeptidase inhibitors kill malaria parasites in culture and are also active in vivo against murine malaria. Functional recombinant enzyme studies have been used to decipher the three-dimensional
Thivierge, Karine, Mathew, Rency T., Nsangou, Desire M., Silva, Fabio L. da, Cotton, Sophie, Skinner-Adams, Tina S., Trenholme, Katharine R., Brown, Christopher L., Stack, Colin M. (R12090), Gardiner, Donald L., Dalton, John P.   +10 more
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Metagenomic analysis reveals significant changes of microbial compositions and protective functions during drinking water treatment. [PDF]

, 2013
published_or_final_versio
CHAO, Y, JU, F, MA, L, Wu, WM, YANG, Y, Zhang, T, Zhang, XX   +6 more
core   +1 more source

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai, Tianxing Pang, Shiyu Peng, Shenshen Zou, Zhiping Deng, Nobuhiro Suzuki, Zhensheng Kang, Ida Bagus Andika, Liying Sun   +8 more
wiley   +1 more source