Results 91 to 100 of about 52,777 (274)
Enhancing Model Interpretability and Accuracy for Disease Progression Prediction via Phenotype-Based Patient Similarity Learning [PDF]
arXiv, 2019 Models have been proposed to extract temporal patterns from longitudinal electronic health records (EHR) for clinical predictive models. However, the common relations among patients (e.g., receiving the same medical treatments) were rarely considered.
arxiv
Haematologica, 2008 Background Patients with chronic lymphocytic leukemia whose cells express CD38 and ZAP-70 and utilize unmutated Ig VH region genes have a very poor prognosis. We studied whether cells expressing CD38 and ZAP-70 are more susceptible to stimulation through
Giovanna Cutrona +11 more
doaj +1 more source
Stage IV Small Lymphocytic Lymphoma Presenting with Unilateral Vision Loss
Case Reports in Oncological Medicine, 2020 Small lymphocytic lymphoma (SLL) is a manifestation of chronic lymphocytic leukemia (CLL) in which malignant B-cell lymphocytes accumulate in the lymph nodes or bone marrow. In this report, we describe the medical course of a patient diagnosed with stage
Christopher Le +4 more
doaj +1 more source
Predicting Treatment Initiation from Clinical Time Series Data via Graph-Augmented Time-Sensitive Model [PDF]
arXiv, 2019 Many computational models were proposed to extract temporal patterns from clinical time series for each patient and among patient group for predictive healthcare. However, the common relations among patients (e.g., share the same doctor) were rarely considered. In this paper, we represent patients and clinicians relations by bipartite graphs addressing
arxiv
Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells
Tumor Biology, 2017 In this study, the combined effect of doxorubicin with cucurbitacin B on survival of anaplastic thyroid carcinoma cells was evaluated. For experiments, 8505C and CAL62 human anaplastic thyroid carcinoma cells were used.
Si Hyoung Kim +6 more
doaj +1 more source
Blinatumomab induces autologous T-cell killing of chronic lymphocytic leukemia cells
Haematologica, 2013 Chronic lymphocytic leukemia is an incurable B-cell malignancy that is associated with tumor cell-mediated T-cell dysfunction. It therefore represents a challenging disease for T-cell immunotherapeutics.
Ryan Wong +5 more
doaj +1 more source
Leukemia Research Reports, 2019 Fc receptor-like 1 (FCRL1) positively regulates B-cell responses and may involve in the pathogenesis of B-cell malignancies. This study examined the expression pattern of FCRL1 in B-cell non-Hodgkin's lymphoma patients using real-time PCR and flow ...
Zahra Yousefi, Nahid Eskandari
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CLEAR: Coverage-based Limiting-cell Experiment Analysis for RNA-seq [PDF]
arXiv, 2018 Direct cDNA preamplification protocols developed for single-cell RNA-seq have enabled transcriptome profiling of precious clinical samples and rare cells without sample pooling or RNA extraction. Currently, there is no algorithm optimized to reveal and remove noisy transcripts in limiting-cell RNA-seq (lcRNA-seq) data for downstream analyses.
arxiv
Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis
iMeta, Volume 1, Issue 4, December 2022., 2022 Intestinal stem cells (ISCs) are protected by their niche and are regulated by Wnt, bone morphogenetic protein, and Notch. ISCs and their relationship with intestinal microbiota provide a feasible pathway to alleviate intestinal diseases. Diverse bacteria‐related postbiotics regulate ISCs and maintain their homeostasis.
Ning Ma +3 more
wiley +1 more source
Ofatumumab – a valid treatment option for chronic lymphocytic leukemia patients
Therapeutics and Clinical Risk Management, 2017 Salma M AlDallal Haematology Laboratory, Amiri Hospital, Kuwait City, Kuwait Abstract: Ofatumumab Arzerra® is a human monoclonal antibody, which induces killing of a panel of tumor B-cell lines and primary tumor cells by the activation of in vitro ...
AlDallal SM
doaj