Results 21 to 30 of about 52,777 (274)

Molecular and cytogenetic characterization of expanded B-cell clones from multiclonal versus monoclonal B-cell chronic lymphoproliferative disorders

Haematologica, 2014
Chronic antigen-stimulation has been recurrently involved in the earlier stages of monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia and other B-cell chronic lymphoproliferative disorders.
Ana Henriques, Arancha Rodríguez-Caballero, Ignacio Criado, Anton W. Langerak, Wendy G. Nieto, Quentin Lécrevisse, Marcos González, Emília Cortesão, Artur Paiva, Julia Almeida, Alberto Orfao   +10 more
doaj   +1 more source

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

Haematologica, 2015
While the renal complications of plasma cell dyscrasia have been well-described, most information in patients with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis is derived from case reports. This is a retrospective analysis of patients
Paolo Strati, Samih H. Nasr, Nelson Leung, Curtis A. Hanson, Kari G. Chaffee, Susan M. Schwager, Sara J. Achenbach, Timothy G. Call, Sameer A. Parikh, Wei Ding, Neil E. Kay, Tait D. Shanafelt   +11 more
doaj   +1 more source

Machine Learning Approaches to Automated Flow Cytometry Diagnosis of Chronic Lymphocytic Leukemia [PDF]

arXiv, 2021
Flow cytometry is a technique that measures multiple fluorescence and light scatter-associated parameters from individual cells as they flow a single file through an excitation light source. These cells are labeled with antibodies to detect various antigens and the fluorescence signals reflect antigen expression.
arxiv  

The role of B-cell receptor inhibitors in the treatment of patients with chronic lymphocytic leukemia

Haematologica, 2015
Chronic lymphocytic leukemia is a malignancy of mature auto-reactive B cells. Genetic and functional studies implicate B-cell receptor signaling as a pivotal pathway in its pathogenesis.
Adrian Wiestner
doaj   +1 more source

A New Deep Learning and XAI-Based Algorithm for Features Selection in Genomics [PDF]

arXiv, 2023
In the field of functional genomics, the analysis of gene expression profiles through Machine and Deep Learning is increasingly providing meaningful insight into a number of diseases. The paper proposes a novel algorithm to perform Feature Selection on genomic-scale data, which exploits the reconstruction capabilities of autoencoders and an ad-hoc ...
arxiv  

Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenic significance in specific subsets of patients

Haematologica, 2011
Background Signaling through the B-cell receptor appears to be a major contributor to the pathogenesis of chronic lymphocytic leukemia. Toll-like receptors bridge the innate and adaptive immune responses by acting as co-stimulatory signals for B cells ...
Eleni Arvaniti, Stavroula Ntoufa, Nikos Papakonstantinou, Tasoula Touloumenidou, Nikolaos Laoutaris, Achilles Anagnostopoulos, Klea Lamnissou, Federico Caligaris-Cappio, Kostas Stamatopoulos, Paolo Ghia, Marta Muzio, Chrysoula Belessi   +11 more
doaj   +1 more source

Zosteriform B-Cell chronic lymphocytic leukemia infiltration

Dermatology Online Journal, 2011
Cutaneous infiltration by leukemic cells is uncommon and may be associated with progression of disease. The authors present the case of a 77-year-old female patient, referred to the dermatology clinic for red, erythematous, pruritic papules, which had suddenly appeared on her left hemithorax, along the C6 dermatome, with a 4-week duration.
Antunes, Joana, Pacheco, David, Travassos, Rita, Filipe, Paulo   +3 more
openaire   +4 more sources

Comparison of microRNA expression in high-count monoclonal B-cell lymphocytosis and Binet A chronic lymphocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia
Background Evidence suggests that monoclonal B-cell lymphocytosis precedes all chronic lymphocytic leukemia cases, although the molecular mechanisms responsible for disease progression are not understood.
Felipe Magalhães Furtado, Priscila Santos Scheucher, Bárbara Amélia Santana, Dalila Lucíola Zanette, Rodrigo do Tocantins Calado, Eduardo Magalhães Rego, Daniel Mazza Matos, Roberto Passetto Falcão   +7 more
doaj   +1 more source

Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies

Haematologica, 2013
While many prognostic markers in B-cell chronic lymphocytic leukemia provide insight into the biology of the disease, few have been demonstrated to be useful in the daily management of patients.
Alessandra Cesano, Omar Perbellini, Erik Evensen, Charles C. Chu, Federica Cioffi, Jason Ptacek, Rajendra N. Damle, Roberto Chignola, James Cordeiro, Xiao-jie Yan, Rachael E. Hawtin, Ilaria Nichele, Jodi R. Ware, Chiara Cavallini, Ornella Lovato, Roberta Zanotti, Kanti R. Rai, Nicholas Chiorazzi, Giovanni Pizzolo, Maria T. Scupoli   +19 more
doaj   +1 more source

Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

Haematologica, 2018
Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease.
Claudia Dürr, Bola S. Hanna, Angela Schulz, Fabienne Lucas, Manuela Zucknick, Axel Benner, Andrew Clear, Sibylle Ohl, Selcen Öztürk, Thorsten Zenz, Stephan Stilgenbauer, Min Li-Weber, Peter H. Krammer, John G. Gribben, Peter Lichter, Martina Seiffert   +15 more
doaj   +1 more source