Results 211 to 220 of about 157,947 (291)

Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemia. [PDF]

Nat Cancer
Cosgun KN, Jumaa H, Robinson ME, Cheng Z, Oulghazi S, Kume K, Fonseca Arce D, Agadzhanian N, Kistner KM, Leveille E, Drivet E, Yu F, Qian Z, Song JY, Chan WC, Xu L, Xiao G, Taketo MM, Kothari S, Davids MS, Schjerven H, Jellusova J, Müschen M.   +22 more
europepmc   +1 more source

Clonal haematopoiesis in chronic lymphocytic leukaemia: Biology, inflammaging and clinical implications in the era of targeted therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
In an ageing and inflamed haematopoietic ecosystem, clonal haematopoiesis and chronic lymphocytic leukaemia may originate from shared or parallel stem cell clones. This interaction modulates the effects of targeted therapies and contributes to cytopenias, cardiovascular toxicity, therapy‐related myeloid neoplasms and Richter transformation.
Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Warthin's Tumor Involved by Monoclonal B-Cell Lymphocytosis: A Case Report. [PDF]

Cureus
Kindy A, Wang Z, Gautam R, Bennett R, Wang Z.   +4 more
europepmc   +1 more source

NCOA2 promotes the return of hematopoietic stem cells to quiescence after irradiation stress by regulating FOXO3a‐dependent mitophagy

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Hematopoietic stem cells (HSCs) are responsible for replenishing blood cells under stress conditions through increasing proliferation and differentiation. After the hematopoietic function has reconstructed, HSCs must re‐enter a quiescent state to avoid their depletion, whereas the underlying mechanisms remain to be elucidated.
Fang Chen, Naicheng Chen, Linjie Wang, Hao Zeng, Yukai Lu, Yanying Liu, Jing Chen, Yang Xu, Mo Chen, Song Wang, Mingqiang Shen, Junping Wang, Mengjia Hu   +12 more
wiley   +1 more source

Understanding hairy cell leukemia in the context of mature B-cell neoplasms: tumor microenvironment and extracellular vesicle contribution to disease pathogenesis. [PDF]

Front Immunol
Ingangi V, Amoroso D, Passaro E, Di Vaia V, Maltoni F, Narimanfar G, Minopoli M, Rosa R, Ametrano M, Di Gennaro E, Broccoli A, Zinzani PL, Catani L, Ciardiello C.   +13 more
europepmc   +1 more source

Survival and Prognostic Factors of 215 Post‐Transplant Lymphoproliferative Disorders After Solid Organ Transplantations in a Finnish Nationwide Population‐Based Study Over 30 Years

Hematological Oncology, Volume 44, Issue 2, March 2026.
ABSTRACT Post‐transplant lymphoproliferative disorder (PTLD) is a rare, dreaded complication of organ transplantation with major clinical challenges. We conducted a nationwide population‐based study of all solid organ transplant (SOT) recipients (n = 6555), both adults and children, over a 30‐year period in Finland.
Terhi K. Friman, Birgitta Salmela, Ilkka Helanterä, Fredrik Åberg, Timo Jahnukainen, Maija Halme, Samuli Vaittinen, Jyri Lommi, Markku O. Pentikäinen, Panu E. Kovanen, Sirpa Leppä, Riikka Räty   +11 more
wiley   +1 more source

Allogeneic hematopoietic stem cell transplantation for mixed-phenotype acute leukemia: a single-center study. [PDF]

Front Immunol
Hao M, Zhao X, Zhang X, Zhai W, Ma Q, Yang D, Pang A, Feng S, He Y, Jiang E, Han M.   +10 more
europepmc   +1 more source

UMG1 Defines a Targetable Subset of T‐Cell Lymphomas and Enables Precision Immunotherapy With a First‐in‐Class CD3ε Bispecific Engager

Hematological Oncology, Volume 44, Issue 2, March 2026.
ABSTRACT T‐cell lymphomas (TCLs) account for a relatively small fraction of lymphoid malignancies and are characterized by highly aggressive course often refractory to current available therapies. We previously reported potent in vitro and in vivo antitumor activity of a Bispecific T‐Cell Engager (UMG1/CD3ε‐BTCE) directed against UMG1, a unique CD43 ...
Daniele Caracciolo, Carlo Gentile, Sara Squillacioti, Stefania Signorelli, Caterina Riillo, Pinuccia Faviana, Francesco Conforti, Katia De Ieso, Elisabetta Procopio, Emanuela Altomare, Nicoletta Polerà, Maria Gaetano, Estelle Balducci, Omer Beganovic, Franca Maria Tuccillo, Patrizia Bonelli, Katia Grillone, Ludovic Lhermitte, Pierosandro Tagliaferri, Pierfrancesco Tassone   +19 more
wiley   +1 more source

Therapeutic Potential of CAR-CIK Cells in Acute Leukemia Relapsed Post Allogeneic Stem Cell Transplantation. [PDF]

Cancers (Basel)
Canichella M, de Fabritiis P, Abruzzese E.   +2 more
europepmc   +1 more source