Results 211 to 220 of about 689,537 (284)

Therapeutic targeting of TGF‐β in lung cancer

The FEBS Journal, Volume 292, Issue 7, Page 1520-1557, April 2025.
Here, we discuss how lung cancer treatment can be transformed by targeting TGF‐β for better outcomes. Inhibiting TGF‐β signaling halts tumor growth, boosts immune response, and enhances treatment efficacy. By tackling TGF‐β's role in epithelial–mesenchymal transition (EMT) and immune evasion, this approach opens new avenues for more effective lung ...
Sajjad Aftabi, Amir Barzegar Behrooz, Marco Cordani, Niloufar Rahiman, Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Stephen Pistorius, Seyedeh Hoda Alavizadeh, Nima Taefehshokr, Saeid Ghavami   +9 more
wiley   +1 more source

Philadelphia chromosome-positive or Philadelphia chromosome-like B-cell precursor acute lymphoblastic leukemia with multilineage involvement in pediatric patients: a report of two cases and literature review. [PDF]

Pharmacogenet Genomics
Lin H, Chen L, Huang R, Xue S, Sun G, Wang C, Shen S, Zhang H, Zheng Y.   +8 more
europepmc   +1 more source

Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective

The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.
This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman, Alexandra Emerson, Peter M. Wilson, Karl A. Mulligan, Robert D. Ladner, Melissa J. LaBonte   +5 more
wiley   +1 more source

Immunodeficiency Diseases and Tumor Immunobiology [PDF]

, 1974
Abramoff, Peter A., Duquesnoy, Rene J.
core   +1 more source

The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy. [PDF]

BMC Med
Zhang MJ, Wen Y, Sun ZJ.
europepmc   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity. [PDF]

Mol Ther
Baatz F, Ghosh A, Herbst J, Polten S, Meyer J, Rhiel M, Maetzig T, Geffers R, Rothe M, Bastone AL, John-Neek P, Frühauf J, Eiz-Vesper B, Bonifacius A, Falk CS, Kaisenberg CV, Cathomen T, Schambach A, van den Brink MRM, Hust M, Sauer MG.   +20 more
europepmc   +1 more source

Serious Infections in Patients Receiving Ibrutinib for Treatment of Lymphoid Cancer

Clinical Infectious Diseases, 2018
Tilly A. Varughese, Y. Taur, Y. Taur, N. Cohen, M. Palomba, M. Palomba, S. Seo, Susan K. Seo, Tobias M. Hohl, Tobias M. Hohl, Gil Redelman-Sidi, Gil Redelman-Sidi   +11 more
semanticscholar   +1 more source

Oral microbiota dysbiosis in pediatric patients undergoing treatment for acute lymphoid leukemia a preliminary study. [PDF]

Genet Mol Biol
Souza AV, Barbosa LV, Castro AAC, Carboni EK, Watanabe FM, Rossati R, Costa LMD, Mesa D, Machado-Souza C.   +8 more
europepmc   +1 more source

Overestimation of Automated Platelet Counts by Blast Fragments in Acute Hypercellular Leukemias: A Retrospective Study Comparing Impedance, Optical (PLT‐O), Fluorescent (PLT‐F), and CD41/CD61 Flow Cytometry Methods

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Acute leukemias with hyperleukocytosis (> 100 × 109/L) can produce cytoplasmic blast fragments that interfere with platelet counts, notably in impedance‐based methods, potentially masking severe thrombocytopenia and increasing hemorrhagic risk.
Victor Bobée, Romain Ravel‐Chapuis, Maïssa Souissi, Catherine Boutet, Dany Bigot, Cédric Paquin, Jorel Gruchet, Virginie Barbay, Vincent Camus, Elsa Bera, Sylvie Daliphard   +10 more
wiley   +1 more source