Results 51 to 60 of about 961,470 (198)

T-cell large granular lymphocytic leukemia and plasma cell disorders

Haematologica, 2018
Although neutropenia is not common as an initial presentation in patients with multiple myeloma (MM), it is a common adverse effect of the therapy used for MM and a more frequent problem in relapsed or refractory disease.
M. Aljama, D. Viswanatha, D. Dingli
semanticscholar   +1 more source

Clinical profile of plasma cell leukemia at Tertiary Care Hospital in Kashmir, India

Journal of Applied Hematology, 2016
Introduction: Plasma cell dyscrasias represent 1.4–2% of all malignancies and among hematologic malignancies; it constitutes 10% of the tumors. Plasma cell dyscrasias are composed of multiple myeloma (MM), and primary and secondary plasma cell leukemia ...
Javvid Muzamil, Shiekh A Aziz, Gull M Bhat, Abdul R Lone, Shuaeb Bhat, Firdousa Nabi   +5 more
doaj   +1 more source

Changing lanes: extending CAR T-cell therapy to high-risk plasma cell dyscrasias

Frontiers in Immunology
Chimeric antigen receptor (CAR) cellular therapies have advanced outcomes in challenging hematologic malignancies like leukemia, lymphoma, and multiple myeloma.
Heather T. Morgan, Benjamin A. Derman, Hong Ma, Shaji K. Kumar   +3 more
doaj   +1 more source

Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma

Haematologica, 2020
Adult T-cell leukemia/leukemia (ATLL) is an aggressive peripheral T-cell malignancy, caused by infection with the human T-cell leukemia virus type 1 (HTLV-1).
Shingo Nakahata, Chilmi Syahrul, Ayako Nakatake, Kuniyo Sakamoto, Maki Yoshihama, Ichiro Nishikata, Yoshinori Ukai, Tadashi Matsuura, Takuro Kameda, Kotaro Shide, Yoko Kubuki, Tomonori Hidaka, Akira Kitanaka, Akihiko Ito, Shigeki Takemoto, Nobuaki Nakano, Masumichi Saito, Masako Iwanaga, Yasuko Sagara, Kosuke Mochida, Masahiro Amano, Kouichi Maeda, Eisaburo Sueoka, Akihiko Okayama, Atae Utsunomiya, Kazuya Shimoda, Toshiki Watanabe, Kazuhiro Morishita   +27 more
doaj   +1 more source

Whole-exome sequencing of primary plasma cell leukemia discloses heterogeneous mutational patterns

OncoTarget, 2015
Primary plasma cell leukemia (pPCL) is a rare and aggressive form of plasma cell dyscrasia and may represent a valid model for high-risk multiple myeloma (MM).
I. Cifola, Marta Lionetti, Eva M. Pinatel, K. Todoerti, E. Mangano, A. Pietrelli, S. Fabris, L. Mosca, V. Simeon, M. Petrucci, F. Morabito, M. Offidani, F. Di Raimondo, A. Falcone, T. Caravita, C. Battaglia, G. De Bellis, A. Palumbo, P. Musto, A. Neri   +19 more
semanticscholar   +1 more source

CASE REPORT: PLASMA CELL LEUKEMIA IN A PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA

Hematology, Transfusion and Cell Therapy
Objective: Plasma cell leukemia (PCL) is a rare and highly aggressive plasma cell neoplasm that develops in 0.5% to 4% of patients with multiple myeloma (MM).
Beyza Oluk, Hüseyin Çiftlik, İlknur Kozanoğlu, Fatih Kula   +3 more
doaj   +1 more source

Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine

International Journal of Molecular Sciences, 2015
Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) which may represent a valid model for high-risk MM. This disease is associated with a very poor prognosis, and unfortunately, it has not significantly improved ...
V. Simeon, K. Todoerti, Francesco La Rocca, A. Caivano, Stefania Trino, Marta Lionetti, L. Agnelli, L. De Luca, I. Laurenzana, A. Neri, P. Musto   +10 more
semanticscholar   +1 more source

The potential role of BCL-2 inhibition in amyloidosis and plasma cell leukemia

Frontiers in Oncology
Plasma cell neoplasms include a spectrum of disorders, such as plasma cell leukemia (PCL) and light chain (AL) amyloidosis, all associated with poor prognosis and limited therapeutic options.
Grigorios Alvanidis, Dimitrios Kotsos, Christina Frouzaki, Amalia Fola, Evdoxia Hatjiharissi   +4 more
doaj   +1 more source

Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry

Leukemia Research Reports, 2018
We retrospectively analyzed twenty-six patients with primary plasma cell leukemia (pPCL) registered from May 2005 until April 2015 by the Kansai Myeloma Forum.
Aya Nakaya, Hideo Yagi, Hitomi Kaneko, Satoru Kosugi, Toru Kida, Yoko Adachi, Hirohiko Shibayama, Takae Kohara, Yuri Kamitsuji, Shin-ichi Fuchida, Nobuhiko Uoshima, Eri Kawata, Hitoji Uchiyama, Yuji Shimura, Takayuki Takahashi, Fumiaki Urase, Kensuke Ohta, Tsuneyoshi Hamada, Kazue Miyamoto, Masayuki Kobayashi, Maki Shindo, Hirokazu Tanaka, Chihiro Shimazaki, Masayuki Hino, Junya Kuroda, Yuzuru Kanakura, Akifumi Takaoari-Kondo, Shosaku Nomura, Itaru Matsumura   +28 more
doaj   +1 more source

Hemorrhagic skin nodules and plaques: A diagnostic clue to underlying primary plasma cell leukemia

Indian Journal of Dermatology, 2016
Plasma cell leukemia (PCL) is a rare lymphoproliferative disorder characterized by a malignant proliferation of plasma cells (PC) in blood and marrow. Cutaneous involvement is very rare in PCL. We present the case of a 45-year-old lady who presented with
Ranjan Gupta, Amiya Kumar Nath, Murugavel Subbian, Debdatta Basu, Abdoul Hamide, Mariette D'Souza   +5 more
doaj   +1 more source