Results 11 to 20 of about 43,548 (209)

Acute Promyelocytic Leukemia [PDF]

Cancers, 2020
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between the promyelocytic leukemia (PML) gene and retinoic acid receptor-α (RARα) [...]
Xavier Thomas, Maël Heiblig
  +6 more sources

Contribution of XN-10 Sysmex Parameters in the Cytological Monitoring of Acute Promyelocytic Leukemia. [PDF]

Int J Lab Hematol
ABSTRACT Objectives The all‐trans‐retinoic acid (ATRA) treatment used in acute promyelocytic leukemia (APL) has the particularity of inducing differentiation of the leukemia cells. As a result, within the same smear, several stages of cellular differentiation of the granular lineage are present, which can make it difficult to distinguish elements when ...
De Maria L, Baldini L, Mouanes Abelin J, Ferrero C, Boursier Y, Berda-Haddad Y, Toulon P.   +6 more
europepmc   +2 more sources

Extramedullary acute promyelocytic leukemia [PDF]

Cancer, 1996
Extramedullary acute promyelocytic leukemia (APL) is rare, and said to be more common after treatment with all-trans retinoic acid (ATRA) than after any other treatment.The case of a child with extramedullary relapse of APL after initial treatment with ATRA and that of an adult whose initial treatment was chemotherapy are presented, and the literature ...
P H, Wiernik, R, De Bellis, P, Muxi, J P, Dutcher   +3 more
openaire   +2 more sources

Acute promyelocytic leukemia

Journal of Nepal Paediatric Society, 2018
Acute promyelocytic leukemia (APL) is the most malignant form of acute leukemia, relatively uncommon in children, rapidly fatal if untreated and several developments have paved the way to make this disease curable. We report a first case to our knowledge in Nepal, a 12 years old boy who was diagnosed as APL and treated with vesanoid 14 years back and ...
Yuranga Weerakkody, Bruno Di Muzio, Daniel Bell   +2 more
  +6 more sources

A thoracic-epidural granulocytic sarcoma case that was diagnosed preceding the onset of and that recurred co-incidental to acute promyelocytic leukemia, which developed after surgical treatment. [PDF]

, 2004
Granulocytic sarcoma or chloroma is a tumor seen in myelocytic leukemia. Spinal epidural onset is rare and is generally seen before or together with the onset of myelocytic leukemia.
Bayraktaroglu, Taner, Borazan, Ali, Demircan, Nejat, Ozdemir, Huseyin, Ozer, Tulay, Savranlar, Ahmet, Ustundag, Yucel   +6 more
core   +1 more source

Acute promyelocytic leukemia with increased bone marrow reticulin fibrosis: Description of three cases and review of the literature

Hematology/Oncology and Stem Cell Therapy, 2018
Pathologic increase in bone marrow reticulin fibrosis can be present in many malignant hematopoietic diseases. In acute leukemia, one-third of patients have some degree of marrow reticulin fibrosis at presentation, which is thought to be related to ...
Iman Abou Dalle, Samer Nassif, Ali Bazarbachi   +2 more
doaj   +1 more source

Regulation of NF-κB by PML and PML-RARα [PDF]

, 2017
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar, Carmody, Ruaidhri J., Chen, Youhai H., Keeshan, Karen, Lindsay, Andrew J., McCaffrey, Mary W., Mitxitorena, Izaskun, Pandolfi, Pier Paolo, Wan, Xiaochun   +8 more
core   +1 more source

Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group

Haematologica, 2018
In standard-risk acute promyelocytic leukemia, recent results have shown that all-trans retinoic acid plus arsenic trioxide combinations are at least as effective as classical all-trans retinoic acid plus anthracycline-based chemotherapy while being less
Lionel Adès, Xavier Thomas, Agnes Guerci Bresler, Emmanuel Raffoux, Olivier Spertini, Norbert Vey, Tony Marchand, Christian Récher, Arnaud Pigneux, Stephane Girault, Eric Deconinck, Claude Gardin, Olivier Tournilhac, Jean Francois Lambert, Patrice Chevallier, Stephane de Botton, Julie Lejeune, Hervé Dombret, Sylvie Chevret, Pierre Fenaux   +19 more
doaj   +1 more source

Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

Hematology, 2003
AbstractThe therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as
Bob, Löwenberg, James D, Griffin, Martin S, Tallman   +2 more
openaire   +2 more sources

The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemia

Haematologica, 2008
Background The gene for preferentially expressed antigen of melanoma (PRAME) has been shown to be over-expressed in acute promyelocytic leukemia, but its actual incidence and clinical impact are still unknown.Design and Methods We studied PRAME ...
Carlos Santamaría, María Carmen Chillón, Ramón García-Sanz, Ana Balanzategui, María Eugenia Sarasquete, Miguel Alcoceba, Fernando Ramos, Teresa Bernal, José Antonio Queizán, María Jesús Peñarrubia, Pilar Giraldo, Jesús F. San Miguel, Marcos Gonzalez   +12 more
doaj   +1 more source