Results 21 to 30 of about 43,548 (209)

Genomic landscapes and clonality of de novo AML [PDF]

, 2013
No abstract ...
Brewin, John, Chevassut, Timothy, Horne, Gillian   +2 more
core   +1 more source

Cellulitis with Leukocytopenia as an Initial Sign of Acute Promyelocytic Leukemia

Case Reports in Dermatology, 2012
Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression.
Sachiko Sakamoto, Naoki Oiso, Masakatsu Emoto, Shusuke Uchida, Ayaka Hirao, Yoichi Tatsumi, Itaru Matsumura, Akira Kawada   +7 more
doaj   +1 more source

Efficacy and the Adverse Effects of Oral Versus Intravenous Arsenic for Acute Promyelocytic Leukemia: A Meta-Analysis of Randomized-Controlled Studies

Technology in Cancer Research & Treatment, 2020
Acute promyelocytic leukemia, a subtype of acute myeloid leukemia, is highly curable. In subgroup of patients with non-high-risk acute promyelocytic leukemia, intravenous arsenic trioxide plus all-trans-retinoic acid is considered the preferred regimen ...
Natthaporn Sasijareonrat MD, Nikolaus Jahn MD, Patompong Ungprasert MD, MS, Weerapat Owattanapanich MD   +3 more
doaj   +1 more source

Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]

, 2017
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo, Ana Cañete, Arguello, Cardoso, Dary, De Luca, Elena Cano, Gebremedhin, Gerster, Grande, Guo, Haussler, Kuwata, Lo-Coco, McLaren, Nervi, North, Ottersbach, O’Donnell, Ramón Muñoz-Chápuli, Rita Carmona, Ross, Testa, West   +23 more
core   +4 more sources

Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute promyelocytic leukemia is characterized by gene rearrangements that always involve the retinoic acid receptor alpha on chromosome 15. In the majority of patients t(15;17) is detected, which generates the promyelocytic leukemia gene/retinoic acid ...
Sarah Cristina Bassi, Eduardo Magalhães Rego   +1 more
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA

Haematologica, 2016
The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, Scott C. Kogan   +9 more
doaj   +1 more source

Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells [PDF]

, 2019
In this work, we have exploited the unique properties of a chimeric archaeal-human ferritin to encapsulate, deliver and release cytochrome c and induce apoptosis in a myeloid leukemia cell line.
Baiocco, P., Boffi, A., Bonamore, A., Fazi, F., Macone, A., Masciarelli, S., Palombarini, Federica, Quaglio, D., Trabuco, M. C.   +8 more
core   +2 more sources

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Braun, S., Duell, T., Gerhartz, Helmut Heinrich, Mittermueller, J., Schmetzer, Helga Maria, Wiesner, D.   +5 more
core   +1 more source

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Beez, Sabine, Demmer, Philipp, Puccetti, Elena   +2 more
core   +3 more sources