Results 251 to 260 of about 213,141 (301)
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Leukemia inhibitory factor: A biological perspective
Journal of Cellular Biochemistry, 1991AbstractThe notion that a single hormone may exert a broad range of effects has become well established. As such, leukemia inhibitory factor (LIF) is a prime example. LIF was initially described, purified, and genetically cloned on the basis of its ability to induce the differentiation and suppress the clonogenicity of the monocytic leukemia cell line,
D J, Hilton, N M, Gough
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The leukemia inhibitory factor (LIF)
The International Journal of Cell Cloning, 1991Leukemia inhibitory factor (LIF) is a glycoprotein able to enforce differentiation and/or suppress clonogenic self-renewal in a number of myeloid leukemic cell lines. When acting on normal embryonic stem cells, it has the opposite action of preventing differentiation commitment.
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Leukemia inhibitory factor in human reproduction
Fertility and Sterility, 2001To describe the clinical findings, expressions, interactions, and clinical implications of leukemia inhibitory factor (LIF) in human reproduction.Review of published articles.Clinical development unit of biotechnology company.None.In the endometrium, LIF is expressed in a menstrual cycle-dependent manner, with the highest level occurring at the time of
A, Lass +3 more
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Leukemia Inhibitory Factor in Human Reproduction
American Journal of Reproductive Immunology, 1998PROBLEM: Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin‐6 family and has different biological actions in various tissue systems. Although named for its ability to inhibit proliferation of a myeloid leukemic cell line by inducing differentiation, it also regulates the growth and differentiation of embryonic stem cells ...
L M, Senturk, A, Arici
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Leukemia Inhibitory Factor Regulates Proopiomelanocortin Transcriptiona
Annals of the New York Academy of Sciences, 1998Abstract: Leukemia inhibitory factor (LIF), a pleiotropic cytokine, is expressed in both fetal and adult pituitary tissue, and LIF immunoreactivity is found in functional human pituitary tumors. LIF induces basal, and augments CRH‐induced, POMC mRNA and ACTH secretion from AtT20 cells.
Ray, David W. +2 more
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Expression of leukemia inhibitory factor in craniopharyngioma
Endocrine Pathology, 1999It has recently been reported that overexpression of leukemia inhibitory factor (LIF) in mice transgenic for LIF causes invagination of the anterior wall of Rathke's pouch leading to the formation of cysts lined by LIF immunoreactive epithelial cells. Strong immunoreactivity was also found in human Rathke's cleft cysts.
A, Tran +5 more
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LIF: Not Just a Leukemia Inhibitory Factor*
Endocrine Reviews, 1991Increasingly it seems that many cytokines are pleiotropic, and individual molecules may have critical roles in several different organ systems. LIF exemplifies this phenomenon: it influences embryogenesis, bone and lipid metabolism, and hematopoietic and nervous system function. Many of LIF's effects are reminiscent of those of IL-1, TNF, and TGF-beta.
R, Kurzrock +4 more
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Leukemia inhibitory factor: Association with intraamniotic infection
American Journal of Obstetrics and Gynecology, 1994Our purpose was to investigate whether leukemia inhibitory factor is associated with intraamniotic infection.A comparative clinical study of amniotic fluid leukemia inhibitory factor concentrations was performed.Leukemia inhibitory factor was undetectable (< 1 ng/ml) by radioreceptor assay during normal pregnancy at midtrimester and at term.
Waring, P. M. +4 more
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Leukemia Inhibitory Factor in Reproduction
2007Objective To describe the clinical findings and implications of leukemia inhibitory factor (LIF) in human reproduction. Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 family and has different biological actions in various tissue systems. Although named for its ability to inhibit proliferation of a myeloid leukemic cell
Levent M. Senturk, Aydin Arid
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Leukemia Inhibitory Factor Signaling in Degenerating Retinas
2014Degeneration of cells in the retina is a hallmark of various inherited and acquired blinding diseases in humans. One of the most challenging problems to establish successful treatments for these diseases is to understand the molecular mechanisms that result in retinal degeneration and to identify endogenous rescue pathways which support cell survival ...
Agca, Cavit, Grimm, Christian
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