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Leukemia Inhibitory Factor in Reproduction
2007Objective To describe the clinical findings and implications of leukemia inhibitory factor (LIF) in human reproduction. Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 family and has different biological actions in various tissue systems. Although named for its ability to inhibit proliferation of a myeloid leukemic cell
Levent M. Senturk, Aydin Arid
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Leukemia Inhibitory Factor Signaling in Degenerating Retinas
2014Degeneration of cells in the retina is a hallmark of various inherited and acquired blinding diseases in humans. One of the most challenging problems to establish successful treatments for these diseases is to understand the molecular mechanisms that result in retinal degeneration and to identify endogenous rescue pathways which support cell survival ...
Agca, Cavit, Grimm, Christian
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Roles of leukemia inhibitory factor receptor in cancer
International Journal of CancerAbstractLeukemia inhibitory factor receptor (LIFR), in complex with glycoprotein 130 (gp130) as the receptor for leukemia inhibitory factor (LIF), can bind to a variety of cytokines and subsequently activate a variety of signaling pathways, including Janus kinase/signal transducer and activator of transcription 3.
Wei Ma +7 more
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Leukemia Inhibitory Factor—A Puzzling Polyfunctional Regulator
Growth Factors, 1992LIF seems likely to have important functions in the early developing embryo and in adult life can influence platelet formation, osteoblast and neuronal function, calcium and lipid metabolism and the production of acute-phase proteins. LIF appears usually to be produced and to function locally in various tissues, an arrangement that would minimize ...
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Leukemia Inhibitory Factor and Human Embryo Implantation
Annals of the New York Academy of Sciences, 2004Abstract: The success of embryonic implantation relies on an ideal cross‐talk between the embryo and the receptive endometrium. This article focuses on the role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation. LIF is a secreted glycoprotein first described as a factor that induced the differentiation of mouse myeloid
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