Results 251 to 260 of about 129,713 (294)
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Leukemia inhibitory factor: A biological perspective
Journal of Cellular Biochemistry, 1991AbstractThe notion that a single hormone may exert a broad range of effects has become well established. As such, leukemia inhibitory factor (LIF) is a prime example. LIF was initially described, purified, and genetically cloned on the basis of its ability to induce the differentiation and suppress the clonogenicity of the monocytic leukemia cell line,
D J, Hilton, N M, Gough
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Leukemia inhibitory factor in human reproduction
Fertility and Sterility, 2001To describe the clinical findings, expressions, interactions, and clinical implications of leukemia inhibitory factor (LIF) in human reproduction.Review of published articles.Clinical development unit of biotechnology company.None.In the endometrium, LIF is expressed in a menstrual cycle-dependent manner, with the highest level occurring at the time of
A, Lass +3 more
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Targeting leukemia inhibitory factor in pancreatic adenocarcinoma
Expert Opinion on Investigational Drugs, 2023The Leukemia Inhibitory Factor (LIF) is a member of the interleukin-6 (IL-6) cytokine family. Known to induce differentiation of myeloid leukemia cells, evidence has accumulated supporting its role in cancer evolution through regulating cell differentiation, renewal, and survival.
Jing Wang +5 more
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LIF: Not Just a Leukemia Inhibitory Factor*
Endocrine Reviews, 1991Increasingly it seems that many cytokines are pleiotropic, and individual molecules may have critical roles in several different organ systems. LIF exemplifies this phenomenon: it influences embryogenesis, bone and lipid metabolism, and hematopoietic and nervous system function. Many of LIF's effects are reminiscent of those of IL-1, TNF, and TGF-beta.
R, Kurzrock +4 more
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Leukemia inhibitory factor is mitogenic to osteoblasts
Bone, 1995Leukemia inhibitory factor (LIF) regulates cell growth and is produced by a variety of tissues, including bone. Previously we have shown that recombinant human LIF induced an increase in osteoclast number, bone formation, and DNA synthesis. In the present study, we have defined the cells in intact bone at which the proliferative effects of LIF occur ...
J, Cornish +3 more
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Domestic Animal Endocrinology, 2010
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the IL-6 family that activates the hypothalamic-pituitary-adrenal axis and promotes corticotrope cell differentiation during development. The aim of this study was to investigate the expression of LIF and its receptor (LIFR) in the canine pituitary gland and in corticotrope adenomas, and to ...
Hanson, J.M., Mol, J.A., Meij, B.P.
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Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the IL-6 family that activates the hypothalamic-pituitary-adrenal axis and promotes corticotrope cell differentiation during development. The aim of this study was to investigate the expression of LIF and its receptor (LIFR) in the canine pituitary gland and in corticotrope adenomas, and to ...
Hanson, J.M., Mol, J.A., Meij, B.P.
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The Leukemia Inhibitory Factor and Its Receptor
1993Publisher Summary This chapter focuses on the leukemia inhibitory factor (LIF) and its receptor that exemplifies many features of cytokine biology. The gene encoding LIF has been cloned and its product characterized extensively; LIF binds to receptors on responsive cells with high and low affinity and the molecular basis for the two types of ...
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Pathology Induced by Leukemia Inhibitory Factor
1993Leukemia inhibitory factor is a glycoprotein growth and differentiation factor with pleiotropic activity. LIF has potent effects on the hematopoietic system, including megakaryocyte progenitor cells. In addition, LIF has bone regeneration activity, induces cachexia and acute-phase response in hepatocytes, and inhibits adipogenesis, to mention the more ...
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The Modulatory Hematopoietic Activities of Leukemia Inhibitory Factor
Leukemia & Lymphoma, 1992Leukemia inhibitory factor (LIF) is a multi-potential cytokine which has been implicated in the hematopoietic regulatory machinery. For example, we have found that LIF is constitutively expressed in marrow stroma. Other investigators have reported that LIF affects remodeling of bone, and that, in concert with other growth factors, it stimulates ...
Z, Estrov +3 more
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Leukemia Inhibitory Factor Regulates Proopiomelanocortin Transcriptiona
Annals of the New York Academy of Sciences, 1998Abstract: Leukemia inhibitory factor (LIF), a pleiotropic cytokine, is expressed in both fetal and adult pituitary tissue, and LIF immunoreactivity is found in functional human pituitary tumors. LIF induces basal, and augments CRHâinduced, POMC mRNA and ACTH secretion from AtT20 cells.
Ray, David W. +2 more
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