Results 261 to 270 of about 213,141 (301)
Some of the next articles are maybe not open access.
Leukemia inhibitory factor: A novel bone-active cytokine
Bone and Mineral, 1990A number of cytokines have been found to be potent regulators of bone resorption and to share the properties originally attributed to osteoclast-activating factor. One such activity, differentiation-inducing factor (DIF, D-factor) from mouse spleen cells, shares a number of biological and biochemical properties with the recently characterized and ...
L R, Reid +7 more
openaire +2 more sources
Leukemia inhibitory factor is mitogenic to osteoblasts
Bone, 1995Leukemia inhibitory factor (LIF) regulates cell growth and is produced by a variety of tissues, including bone. Previously we have shown that recombinant human LIF induced an increase in osteoclast number, bone formation, and DNA synthesis. In the present study, we have defined the cells in intact bone at which the proliferative effects of LIF occur ...
J, Cornish +3 more
openaire +2 more sources
Leukemia Inhibitory Factor—A Puzzling Polyfunctional Regulator
Growth Factors, 1992LIF seems likely to have important functions in the early developing embryo and in adult life can influence platelet formation, osteoblast and neuronal function, calcium and lipid metabolism and the production of acute-phase proteins. LIF appears usually to be produced and to function locally in various tissues, an arrangement that would minimize ...
openaire +2 more sources
Pathology Induced by Leukemia Inhibitory Factor
1993Leukemia inhibitory factor is a glycoprotein growth and differentiation factor with pleiotropic activity. LIF has potent effects on the hematopoietic system, including megakaryocyte progenitor cells. In addition, LIF has bone regeneration activity, induces cachexia and acute-phase response in hepatocytes, and inhibits adipogenesis, to mention the more ...
openaire +2 more sources
Leukemia Inhibitory Factor and Human Embryo Implantation
Annals of the New York Academy of Sciences, 2004Abstract: The success of embryonic implantation relies on an ideal cross‐talk between the embryo and the receptive endometrium. This article focuses on the role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation. LIF is a secreted glycoprotein first described as a factor that induced the differentiation of mouse myeloid
openaire +2 more sources
Prevention of Chemotherapy-Induced Neuropathy: Leukemia Inhibitory Factor
Clinical Cancer Research, 2005Peripheral neurotoxicity is a dose-limiting and disabling side effect of several important chemotherapeutic agents. In particular, vincristine, cisplatin, oxaliplatin, paclitaxel, and docetaxel are frequently used antineoplastic agents, which are known causes of a peripheral neuropathy.
openaire +2 more sources
The Leukemia Inhibitory Factor and Its Receptor
1993Publisher Summary This chapter focuses on the leukemia inhibitory factor (LIF) and its receptor that exemplifies many features of cytokine biology. The gene encoding LIF has been cloned and its product characterized extensively; LIF binds to receptors on responsive cells with high and low affinity and the molecular basis for the two types of ...
openaire +2 more sources