Results 61 to 70 of about 4,728,853 (203)

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

Communications Biology, 2023
All except one cytokine of the Interleukin (IL-)6 family share glycoprotein (gp) 130 as the common β receptor chain. Whereas Interleukin (IL-)11 signal via the non-signaling IL-11 receptor (IL-11R) and gp130 homodimers, leukemia inhibitory factor (LIF ...
Puyan Rafii, Christiane Seibel, Hendrik T. Weitz, Julia Ettich, Anna Rita Minafra, Patrick Petzsch, Alexander Lang, Doreen M. Floss, Kristina Behnke, Karl Köhrer, Jens M. Moll, Jürgen Scheller   +11 more
doaj   +1 more source

Leukemia Inhibitory Factor Suppresses NKG2D mRNA Expression and Presentation on Human Natural Killer Cells

Iranian Journal of Allergy, Asthma and Immunology, 2021
Leukemia inhibitory factor (LIF) is a multi-functional cytokine secreted from cells such as lymphocytes and hepatocytes. This study aimed to evaluate the effect of LIF on natural killer group 2 member D (NKG2D) receptors' expression and presentation on ...
Zahra Abdoli, Mohammad-Ali Assarehzadegan, Mohammad Hassan Pipelzadeh, Sara Iranparast, Nader Dashti Gerdabi, Mehdi Parsanahad, Ali Khodadadi   +6 more
doaj   +1 more source

Agrin Pathway is Controlled by Leukemia Inhibitory Factor (LIF) in Murine Implantation

Journal of Reproduction and Development, 2009
Agrin is the heparan sulfate proteoglycan (HSPG) that is well known as the molecule that aggregates acetylcholine receptor (AChR) through muscle specific kinase (MuSK) and rapsyn at neuromuscular junctions. HSPGs are spatiotemporally expressed in embryonic and maternal tissues during implantation.
TERAKAWA, Jumpei, HONDO, Eiichi, SUGIYAMA, Makoto, WAKITANI, Shoichi, STEWART, Colin L., KISO, Yasuo   +5 more
openaire   +3 more sources

Evaluating Thiram‐Induced Embryotoxicity Using Integrated In Silico, In Vitro, and Transcriptomic Approaches

Environmental Toxicology, EarlyView.
ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho, Chun‐Wei Tung, B. Linju Yen, Chen‐Yi Weng, Ju‐Hsin Hsu, Ming‐Hsien Tsai, Salim Arrokhman, Pinpin Lin   +7 more
wiley   +1 more source

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
Pluripotent mouse embryonic stem (ES) cells can be expanded in large numbers in vitro owing to a process of symmetrical self-renewal. Self-renewal entails proliferation with a concomitant suppression of differentiation.
Burdon, Tom, Burdon, T., Smith, A., Savatier, Pierre, Smith, Austin   +4 more
core   +1 more source

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

The causal relationship in hypertensive encephalopathy: mechanistic analysis of five specific circulating cytokines

Open Medicine
To investigate the causal relationship between genetically predicted levels of five circulating cytokines – CXCL11, IL-2, IL-4, leukemia inhibitory factor (LIF), and neurotrophin-3 (NT-3) – and the risk of hypertensive encephalopathy using a two-sample ...
Zhang Pengfei, Huang Yijia, Li Haoying, Zhang Can, Chen Zhiren   +4 more
doaj   +1 more source

Identification of Prognostic Factors and Regulatory Pathways in Porto‐Sinusoidal Vascular Disorder

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background and Aims Porto‐sinusoidal vascular disorder (PSVD) is a rare liver condition characterized by specific histological features primarily affecting the hepatic sinusoidal and periportal vasculature, in the absence of cirrhosis. This study aimed to identify prognostic factors and regulatory pathways associated with PSVD by integrating ...
Subin Heo, Do Kyung Yoon, Soyeon Shin, Dami Youn, Youngeun Yoo, In Hye Song, Hyo Jeong Kang, Young‐In Yoon, Kyunggon Kim, Seung Soo Lee, Sung Won Chung, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young‐Suk Lim, Han Chu Lee, Mark Muthiah, Ho‐Su Lee, Won‐Mook Choi   +19 more
wiley   +1 more source

Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF

, 2001
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine involved in early conceptus development in pig. We isolated a PAC clone containing the porcine LIF gene and determined the complete DNA sequence of the gene, which spans about 6.3 kb and consists
Brenig, Bertram, Spotter, A., Distl, O., Leeb, Tosso, Drogemuller, Cord, Kuiper, H.   +5 more
core   +1 more source