Results 61 to 70 of about 8,824 (256)

Pathophysiology of vascular dementia [PDF]

, 2009
The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear.Conventional definitions identify the patients too late, miss subjects with cognitive impairment short of dementia ...
Francesco Iemolo, Giovanni Duro, Claudia Rizzo, Laura Castiglia, Vladimir Hachinski, Calogero Caruso   +5 more
core   +2 more sources

Amyloid‐related imaging abnormalities (ARIA) in anti‐amyloid therapies for Alzheimer's disease: An update from the Alzheimer's Association ARIA workgroup

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract In 2011, a workgroup of the Alzheimer's Association Research Roundtable introduced recommendations for detecting and monitoring amyloid‐related imaging abnormalities (ARIA) in Alzheimer's disease (AD) clinical trials. Since then, anti‐amyloid immunotherapies have received regulatory approval for AD treatment and are beginning to enter clinical
Ellis S. van Etten, Simin Mahinrad, Joshua D. Grill, Stephen Salloway, Alireza Atri, Petrice M. Cogswell, Tammie L. S. Benzinger, Takeshi Iwatsubo, Costantino Iadecola, Cynthia A. Lemere, James A. R. Nicoll, Steven M. Greenberg, Maria C. Carrillo, Clifford R. Jack Jr, Reisa A. Sperling   +14 more
wiley   +1 more source

Determinants of post-stroke cognitive impairment: analysis from VISTA [PDF]

, 2017
BACKGROUND: Post-stroke cognitive impairment (PSCI) occurs commonly and is linked with development of dementia. We investigated the relationship between demographic, clinical and stroke symptoms at stroke onset and the presence of PSCI at 1 and 3 ...
Ali, Bamford, Barba, Ben Assayag, Buracchio, Desmond, Feher, Godefroy, Jacquin, Kjörk, Lees, Leys, Pendelbury, Pendlebury, Pendlebury, Poggesi, Sachdev, Verghese   +17 more
core   +2 more sources

New Clinical Relevance of Leukoaraiosis [PDF]

Stroke, 1998
To the Editor: Changes in the cerebral white matter are detected with high frequency by CT and MRI in aged individuals.1 The descriptive term leukoaraiosis, meaning rarefaction of the white matter, was proposed some 10 years ago to describe these radiological changes.2 Although the mechanism of leukoaraiosis in different clinical conditions such as ...
Pantoni, L, Inzitari, D
openaire   +2 more sources

A Rare Case Report of Neuroimaging, Electrophysiological, and Dynamic Laryngoscopy Studies in a Stroke Patient of Foix‐Chavany‐Marie Syndrome

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Foix‐Chavany‐Marie Syndrome (FCMS), also known as opercular syndrome, is a rare neurological disorder caused by an ischemic stroke that results in autonomic‐voluntary dissociation. In this case report, we describe a patient who presented with an acute right frontal and parietal cortical lesion, in addition to a remote infarction in the left ...
Lu Xia, Liyan Cai, Xin Chen, Wei Huang, Cen Chen, Shinian Yang, Qing Chen, Yuanyuan Zhu   +7 more
wiley   +1 more source

Beyond the Surface: Delving Deeper Into Leukoaraiosis With Multivoxel Magnetic Resonance Spectroscopy

Инновационная медицина Кубани
Objective: To investigate metabolite changes in patients with leukoaraiosis employing multivoxel magnetic resonance spectroscopy (MRS) with the focus on periventricular white matter and explicate the biochemical alterations associated with leukoaraiosis ...
Ragitha Ramesh, Arunan Subbiah, Senthilkumar Aiyappan, Sabari Ramesh   +3 more
doaj   +1 more source

Red Blood Cell Distribution Width Is Associated with Severity of Leukoaraiosis.

PLoS ONE, 2016
Red blood cell distribution width (RDW) is one of the routine hematologic parameters reported in the complete blood count test, which has been recognized as strong prognostic marker for various medical conditions, especially cardiovascular disease.
Han-Bin Lee, Jinkwon Kim, Seung-Hun Oh, Sang-Heum Kim, Hyun-Sook Kim, Won-Chan Kim, Soonhag Kim, Ok-Joon Kim   +7 more
doaj   +1 more source

Abnormal blood pressure circadian rhythms are relevant to cerebral infarction and Leukoaraiosis in hypertensive patients

BMC Neurology, 2020
Background To investigate the relationships between blood pressure (BP) circadian rhythms and acute cerebral infarction (ACI), silent cerebral infarction (SCI) and the severity of leukoaraiosis in hypertensive patients.
Kang Yang, Xiaodong Zhu, Yulan Feng, Fanxia Shen, Jie Chen, Ningzhen Fu, Jialan Sun, Yi Fu   +7 more
doaj   +1 more source

Leukoaraiosis – new concepts and modern imaging [PDF]

Polish Journal of Radiology, 2018
Leukoaraiosis is a pathological appearance of the brain white matter, which has long been believed to be caused by perfusion disturbances within the arterioles perforating through the deep brain structures. Due to its complex etio­pathogenesis and clinical relevance, leukoaroisosis has been investigated in a multitude of studies.
Marek, Marta, Horyniecki, Maciej, Frączek, Michał, Kluczewska, Ewa   +3 more
openaire   +2 more sources

Druggable genome‐wide Mendelian randomization analysis identifies potential treatment targets in vascular dementia

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract BACKGROUND There are currently no US Food and Drug Administration‐approved treatments for vascular dementia (VaD). Genome‐wide approaches have successfully identified druggable targets and treatments for various disorders. In this study, we performed druggable genome‐wide two‐sample Mendelian randomization (2SMR) analysis to identify possible ...
Matthew J. Lennon, Ying Xu, Anbupalam Thalamuthu, Karen Mather, Perminder S. Sachdev   +4 more
wiley   +1 more source