Results 71 to 80 of about 3,801 (177)

A Novel and Simple Score to Predict Embolic or Atherosclerotic Middle Cerebral Artery Occlusion Before Mechanical Thrombectomy: AHOC Score

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This study developed and validated the novel AHOC score, a simple pre‐thrombectomy tool for predicting stroke etiology (embolism vs. intracranial atherosclerosis) in acute middle cerebral artery occlusion. This score integrates four key clinical/imaging variables—atrial fibrillation, hyperdense artery sign, stenosis/occlusion in other arteries, and ...
Hudie Zhang   +17 more
wiley   +1 more source

Editorial Comment—The Progression of Leukoaraiosis [PDF]

open access: yesStroke, 2003
Leukoaraiosis (LA), the presence of rarefaction of the white matter originally described on CT1 but now more commonly recognized on MRI, was originally largely ignored as an inconsequential finding seen in association with cerebrovascular disease. More recently, it has become clear that LA impairs cognition.2 When LA is sufficiently prominent to be ...
openaire   +2 more sources

Validation Conditions for the Use of Diffusion Tensor Imaging for Neuroprognosis: A Clinical and Technical Review

open access: yesInternational Journal of Biomedical Imaging, Volume 2026, Issue 1, 2026.
In the growing field of neuroprognosis in intensive care patients, the use of diffusion tensor imaging (DTI) MRI to quantify white matter integrity is particularly promising, with solid demonstrations for predicting outcomes in cardiac arrest and severe traumatic brain injury.
Pierre Simeone   +14 more
wiley   +1 more source

Autoimmune and paraneoplastic encephalitis–associated neuronal autoantibodies with serial EEG in adults with unexplained new‐onset seizures or worsening epilepsy

open access: yesEpilepsia Open, Volume 10, Issue 6, Page 1978-1989, December 2025.
Abstract Objective Unexplained seizures or worsening epilepsy in adult patients may be associated with specific neuronal or onconeuronal antibodies. We propose that comprehensive antibody testing is beneficial for adults with new‐onset seizures or aggravated epilepsy without a predetermined etiology.
Chang‐Yu Edward Cheng   +5 more
wiley   +1 more source

Shared genes and pathways in dementia: Insights from genome‐wide association studies

open access: yesAlzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract Dementia, a collective term for neurodegenerative disorders marked by cognitive decline, affects millions worldwide, and is expected to rise significantly in prevalence. Genome‐wide association studies (GWASs), as highlighted in this review, have revolutionized our understanding of dementia by identifying contributing genetic loci and pathways,
Kyle J. Loi   +6 more
wiley   +1 more source

Frequency of Microvascular Pathology and Hippocampal Atrophy on Magnetic Resonance Imaging in a Community Study of Alzheimer's Disease with Blood‐Based Biomarkers

open access: yesAnnals of Neurology, Volume 98, Issue 5, Page 1027-1043, November 2025.
Objective Blood‐based biomarkers for Alzheimer's disease (AD), representing antemortem indicators of AD pathophysiology, have greatly improved the accuracy of diagnosis. However, these biomarkers may not capture a frequent coincident pathology, such as cerebrovascular disease.
Tamil Iniyan Gunasekaran   +12 more
wiley   +1 more source

P8.16 WHITE MATTER LESIONS ARE ASSOCIATED WITH A SIGNIFICANT DECREASE IN THE METABOLISM OF THE BRAIN GREY-MATTER FROM OLDER HYPERTENSIVE PATIENTS

open access: yesArtery Research, 2015
White matter lesions, described as leukoaraiosis, are frequently documented in older hypertensive patients, but their consequence on brain metabolism remains debated.
Antoine Verger   +3 more
doaj   +1 more source

Correlates of telomere length shortening in peripheral leukocytes of HIV-infected individuals and association with leukoaraiosis.

open access: yesPLoS ONE, 2019
Telomere length (TL) is a marker of cellular and biological aging. Human immunodeficiency virus (HIV) infection has been reported to be associated with short TLs, which suggests that accelerated biological aging occurs in some cellular compartments of ...
Rumi Minami   +2 more
doaj   +1 more source

Hemispheric Asymmetry of White Matter Hyperintensity in Association With Lacunar Infarction

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background White matter hyperintensities (WMHs) are commonly asymmetric between hemispheres but for unknown reasons. We investigated asymmetric WMHs associated with lacunar infarcts.
Wi‐Sun Ryu   +28 more
doaj   +1 more source

CT Abnormalities with HIV Encephalopathy

open access: yesPediatric Neurology Briefs, 1993
Qualitative analysis of 100 consecutive computed tomographic (CT) studies of the brain in children with symptomatic but untreated acquired immunodeficiency syndrome is reported from the National Institutes of Health, Bethesda, MD, and the Children’s ...
J Gordon Millichap
doaj   +1 more source

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