Results 1 to 10 of about 14,971 (215)

Host–Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity [PDF]

Toxins, 2020
Staphylococcal bi-component pore-forming toxins, also known as leukocidins, target and lyse human phagocytes in a receptor-dependent manner. S-components of the leukocidins Panton-Valentine leukocidin (PVL), γ-haemolysin AB (HlgAB) and CB (HlgCB), and leukocidin ED (LukED) specifically employ receptors that belong to the class of G-protein coupled ...
Angelino T. Tromp, Michiel Van Gent, Joris P. Jansen, Lisette M. Scheepmaker, Anneroos Velthuizen, Carla J.C. De Haas, Kok P.M. Van Kessel, Bart W. Bardoel, Michael Boettcher, Michael T. McManus, Jos A.G. Van Strijp, Robert Jan Lebbink, Pieter-Jan A. Haas, András N. Spaan   +13 more
semanticscholar   +6 more sources

Characterization of a leukocidin identified in Staphylococcus pseudintermedius [PDF]

PLOS ONE, 2018
Las infecciones bacterianas por Staphylococcus pseudintermedius son la causa más común de infecciones cutáneas (pioderma) que afectan a los perros. Las leucocidinas formadoras de poros de dos componentes son una familia de toxinas potentes secretadas por estafilococos y consisten en componentes S (lento) y F (rápido).
Mohamed A. Abouelkhair, David A. Bemis, Richard J. Giannone, Linda A. Frank, Stephen A. Kania   +4 more
semanticscholar   +5 more sources

Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

Italian Journal of Pediatrics, 2021
Background Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections.
M. Castellazzi, S. Bosis, I. Borzani, C. Tagliabue, R. Pinzani, P. Marchisio, Giada Maria Di Pietro   +6 more
semanticscholar   +2 more sources

Severe infections of Panton-Valentine leukocidin positive Staphylococcus aureus in children [PDF]

Medicine, 2019
Infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus (PVL-SA) mostly present as recurrent skin abscesses and furunculosis.
Bernuth, Horst von, Bührer, Christoph, Gratopp, Alexander, Hanitsch, Leif Gunnar, Holzhauer, Susanne, Hoppe, Pia-Alice, Humme, Daniel, Kallinich, Tilmann, Kieslich, Moritz, Krüger, Renate, Lala, Birgit, Lau, Susanne, Leistner, Rasmus, Niebank, Michaela, Pokrywka, Anna, Ringe, Hannelore, Schaper, Anne-Sophie, Schröder, Jennyver-Tabea, Schwarz, Carsten, Staab, Doris, Stegemann, Miriam Songa, Thee, Stephanie, Varnholt, Verena, Weber-Carstens, Steffen, Wendt, Anke   +24 more
core   +2 more sources

Studying Staphylococcal Leukocidins: A Challenging Endeavor

Frontiers in Microbiology, 2020
Staphylococcus aureus is a well-known colonizer of the human skin and nose, but also a human pathogen that causes a wide spectrum of diseases. It is well established that S. aureus secretes an arsenal of virulence factors that have evolved to circumvent the human immune system. A major group of S.
Tromp, Angelino T., van Strijp, Jos A.G.
openaire   +5 more sources

Panton-Valentine Leukocidin–Secreting Staphylococcus aureus Pneumonia Complicating COVID-19

Emerging Infectious Diseases, 2020
Necrotizing pneumonia induced by Panton-Valentine leukocidin–secreting Staphylococcus aureus is a rare but life-threatening infection that has been described in patients after they had influenza.
C. Duployez, Rémi Le Guern, C. Tinez, A. Lejeune, L. Robriquet, S. Six, C. Loïez, F. Wallet   +7 more
semanticscholar   +3 more sources

Staphylococcus aureus isolates from Eurasian Beavers (Castor fiber) carry a novel phage-borne bicomponent leukocidin related to the Panton-Valentine leukocidin

Scientific Reports, 2021
Staphylococcus aureus can be a harmless coloniser, but it can also cause severe infections in humans, livestock and wildlife. Regarding the latter, only few studies have been performed and knowledge on virulence factors is insufficient.
S. Monecke, A. Feßler, Sindy Burgold-Voigt, Henrike Krüger, K. Mühldorfer, G. Wibbelt, E. Liebler-Tenorio, M. Reinicke, S. Braun, D. Hanke, Celia Diezel, E. Müller, I. Loncaric, S. Schwarz, R. Ehricht   +14 more
semanticscholar   +2 more sources

Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome

Emerging Microbes and Infections, 2019
Cell death mechanisms are central to combat infectious microbes and to drive pathological inflammation. One such mechanism, the inflammasome, controls infection through either activation of caspase-1 and the subsequent secretion of the mature pro ...
Noam Baram, H. Cohen, L. Edry-Botzer, D. Salomon, M. Gerlic   +4 more
semanticscholar   +3 more sources

Association of Panton Valentine Leukocidin (PVL) genes with methicillin resistant Staphylococcus aureus (MRSA) in Western Nepal: a matter of concern for community infections (a hospital based prospective study) [PDF]

BMC Infectious Diseases, 2016
BACKGROUND: Methicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen associated with nosocomial and community infections. Panton Valentine leukocidin (PVL) is considered one of the important virulence factors of S.
A Gravet, A Holmes, Abhishek Gaur, AL Genestier, AP Magiorakos, B Shrestha, C Eckhardt, Clinical and Laboratory Standards Institute, Dharm R. Bhatta, DJ Geha, DR Bhatta, Dwij R. Bhatta, F Vandenesch, G Lina, G Prevost, Gopal Nath, H Kaur, H Linde, HC Maltezou, IG Bae, IM Moussa, JA McClure, KO Bhutia, Kush Kumar, LG Miller, Lina M. Cavaco, M Li, ND Souza, P Panton, S Afroz, SA Havaei, Shishir Gokhale, SJ Campbell, WJ Munckhof   +33 more
core   +2 more sources

Panton-Valentine Leukocidin–producing Staphylococcus aureus

Emerging Infectious Diseases, 2006
To the Editor: Panton-Valentine leukocidin (PVL) is a cytotoxin produced by Staphylococcus aureus that causes leukocyte destruction and tissue necrosis (1). Although produced by
Amos Adler, Violeta Temper, Colin S. Block, Nitsa Abramson, Allon E. Moses   +4 more
openaire   +4 more sources