SarS and Rot are necessary for the repression of lukED and lukSF-PV in Staphylococcus aureus [PDF]
Microbiology Spectrum, 2023 Staphylococcus aureus is an opportunistic pathogen that employs an array of different virulence factors to evade the immune system. The bi-component pore-forming leukocidins are of particular importance for their ability to target and kill phagocytes ...
Exene E. Anderson +2 more
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Microbiology Spectrum, 2023 Staphylococcus aureus is a clinically important bacterial pathogen that has become resistant to treatment with most routinely used antibiotics. Alternative strategies, such as vaccination and phage therapy, are therefore actively being investigated to ...
Matthew James Bottomley +2 more
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Comparative genomics of endemic Staphylococcus aureus ST1 in New Zealand [PDF]
mSphereStaphylococcus aureus is a major zoonotic bacterial pathogen that causes a broad spectrum of human and animal diseases, including skin infections, sepsis, endocarditis, and bovine mastitis.
Emma M. Voss +12 more
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Studying Staphylococcal Leukocidins: A Challenging Endeavor
Frontiers in Microbiology, 2020 Staphylococcus aureus is a well-known colonizer of the human skin and nose, but also a human pathogen that causes a wide spectrum of diseases. It is well established that S.
Jos A G Van Strijp +2 more
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TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection [PDF]
Frontiers in Immunology, 2023 BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He +6 more
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BMC Microbiology, 2018 Background Staphylococcus aureus is a leading cause of Gram-positive bacterial infections worldwide; however, the treatment of S. aureus infection has become increasingly difficult due to the prevalence of methicillin-resistant S.
Guang Yang, Chenghua Liu, Yaping Gao
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Staphylococcus aureus biofilm extracellular DNA neutralizes the antimicrobial activity of histone H3 [PDF]
npj Biofilms and MicrobiomesStaphylococcus aureus is an opportunistic pathogen that forms robust biofilms. This poses several challenges to the host in successfully clearing the pathogen, thus leading to chronic infections. S.
Pranav S. J. B. Rana +4 more
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The Relative Importance of Cytotoxins Produced by Methicillin-Resistant Staphylococcus aureus Strain USA300 for Causing Human PMN Destruction [PDF]
MicroorganismsStaphylococcus aureus (S. aureus) is a prominent Gram-positive bacterial pathogen that expresses numerous cytotoxins known to target human polymorphonuclear leukocytes (PMNs or neutrophils).
Tyler K. Nygaard +7 more
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Prevalence and genetic characterization of methicillin-resistant Staphylococcus aureus in Commercial aquaculture farms in Egypt [PDF]
Scientific ReportsMethicillin-resistant Staphylococcus aureus (MRSA) is a major public health concern due to its resistance and pathogenic potential. This study investigated the prevalence and genetic characterization of MRSA and methicillin-sensitive S.
Maged El-Ashker +7 more
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The anti-biofilm compound 4-ethoxybenzoic acid inhibits Staphylococcus aureus virulence factor production via a putative 4EB-binding pocket in key virulence-associated proteins [PDF]
Frontiers in MicrobiologyThere is a need for dual action anti-virulence and anti-biofilm agents that target the opportunistic pathogen Staphylococcus aureus. Previous research determined that 0.8 mg/mL 4-ethoxybenzoic acid (4EB) reduced S.
Caroline C. Taylor +10 more
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