Results 41 to 50 of about 1,692 (168)

Targeting of Staphyloxanthin and α‐Hemolysin by Natural Compound L‐Malic Acid Suppresses Staphylococcus aureus Virulence

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
L‐malic acid, a natural TCA cycle intermediate, attenuates the virulence of Staphylococcus aureus through dual metabolic and regulatory mechanisms. It redirects central carbon flux away from the mevalonate pathway and inhibits the key enzyme CrtO, suppressing staphyloxanthin biosynthesis and impairing bacterial resistance to oxidative stress ...
Li Shen, Bingjie Wang, Jinjin Yang, Xinru Yuan, Zhixuan Chen, Can Yang, Jiana Fu, Haojin Gao, Weihua Han, Junhong Shi, Fangyou Yu, Jingyi Yu   +11 more
wiley   +1 more source

Prevalence of Genes Encoding Bi-Component Leukocidins among Clinical Isolates of Methicillin–Resistant Staphylococcus aureus [PDF]

Iranian Journal of Public Health, 2010
"nBackground: Staphylococcus aureus has been recognized as a major human pathogen and is the major cause of nosocomial infections. Gamma-toxin, leukocidin and other bi-component toxins are a family of proteins encoded by the hlg and luk-PV ...
SA Havaei, S Ohadian Moghadam, MR Pourmand, J Faghri   +3 more
doaj   +2 more sources

Comparative secretome analysis of Staphylococcus aureus strains with different within-herd intramammary infection prevalence

Virulence, 2022
Staphylococcus aureus is a major pathogen causing intramammary infection and mastitis in dairy cows. S. aureus genotypes (GT) can differ significantly in their ability to diffuse and persist in the herd; while the association of virulence gene carriage ...
M. Filippa Addis, Salvatore Pisanu, Valentina Monistero, Alessandra Gazzola, Martina Penati, Joel Filipe, Susanna Di Mauro, Paola Cremonesi, Bianca Castiglioni, Paolo Moroni, Daniela Pagnozzi, Sebastiana Tola, Renata Piccinini   +12 more
doaj   +1 more source

Panton-Valentine Leukocidin Genes inStaphylococcus aureus

Emerging Infectious Diseases, 2006
The pathogenicity of Staphylococcus aureus depends on various bacterial surface components and extracellular proteins. However, the precise role of single virulence determinants in relation to infection is hard to establish. The frequent recovery of staphylococcal isolates that produce leukocidal toxins from patients with deep skin and soft tissue ...
Melles, Damian, Leeuwen, Willem, Boelens, Hélène, Peeters, Justine, Verbrugh, Henri, Belkum, Alex   +5 more
openaire   +4 more sources

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source

Hospital‐Associated Antimicrobial Resistant Bacteria on 95 Mobile Phones: An International Metagenomic “Phonome” Analysis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
On average, phones harbored 3.62 of the top 10 killers and 2.49 ESKAPE organisms. In total, 667 VFGs (8621 Hits) and 262 ARGs (2475 Hits) were identified on 95 mobile phones. Mobile phones serve as a platform for horizontal gene transfer and AMR development.
Adrian Goldsworthy, Matthew Olsen, Nchafatso G. Obonyo, Peter Jones, Simon McKirdy, Abiola Senok, Rashed Alghafri, Rose Ghemrawi, Reem Almheiri, Oystein Tronstad, Jacky Y. Suen, John F. Fraser, Lotti Tajouri   +12 more
wiley   +1 more source

Panton-Valentine Leukocidin–Positive MRSA, Shanghai

Emerging Infectious Diseases, 2010
To the Editor: The development of methicillin resistance in community strains of Staphylococcus aureus is a notable step in the evolution of this pathogen. Unlike their equivalents in the hospital environment, community-associated methicillin-resistant S.
Li-Zhong Han, Pak-Leung Ho, Yu-Xing Ni, Hong Zhang, Yan-Qun Jiang, Hai-Qing Chu, Yang Sun, Yi-Bo Zhang   +7 more
openaire   +3 more sources

Burn Wound Infections With Staphylococcus aureus: Clinical Characteristics and Risk Factors for Methicillin‐Resistant Strains

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT This study aimed to systematically delineate the clinical characteristics and identify the key risk factors associated with methicillin‐resistant Staphylococcus aureus (MRSA) infections in burn patients, thereby informing targeted preventive measures and therapeutic strategies.
Xiaolan Hong, Shaobo Zhou, Qinghua Cai, Yuanyuan Cai, Zhaohong Chen, Wanting Zhao, Yongjian Ye, Xubo Dai   +7 more
wiley   +1 more source

Occurrence of toxin genes in Staphylococcus pseudintermedius from diseased dogs and other domestic and wild species

Journal of Infection in Developing Countries, 2018
Introduction: Staphylococcus pseudintermedius is coagulase-positive species of the Staphylococcus intermedius group. It is an opportunistic pathogen that can cause infection in various parts of the body and has a zoonotic potential.
Leticia Camara Pitchenin, Laila Natasha Santos Brandão, Janaina Marcela Assunção Rosa, Francielle Cristina Kagueyama, Alvair da Silva Alves, Ícaro Sergio Magalães Rocha, Luciano Nakazato, Valéria Dutra   +7 more
doaj   +1 more source

Staphylococcus aureus and Staphylococcus lugdunensis Act in Concert to Disrupt the Nasal Epithelial Barrier

Clinical and Translational Allergy, Volume 16, Issue 5, May 2026.
ABSTRACT Introduction Chronic rhinosinusitis (CRS) pathophysiology and its link to microbiome is an area of ongoing investigation. Certain pathogens, in particular Staphylococcus aureus described to contribute to recalcitrant CRS. In addition, different species of coagulase negative staphylococci (CoNS) are frequently isolated from the sinonasal cavity
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Gohar Shaghayegh, Isabella Burdon, Emma F. Barry, Kevin Aaron Fenix, P. J. Wormald, Alkis J. Psaltis, Sarah Vreugde   +9 more
wiley   +1 more source