Results 31 to 40 of about 1,692 (168)

Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection

mBio, 2018
Staphylococcus aureus is a Gram-positive opportunistic pathogen that causes superficial and invasive infections in the hospital and community. High mortality from infection emphasizes the need for improved methods for prevention and treatment. Although S.
Adam J. Pelzek, Bo Shopsin, Emily E. Radke, Kayan Tam, Beatrix M. Ueberheide, David Fenyö, Stuart M. Brown, Qianhao Li, Ada Rubin, Yi Fulmer, William K. Chiang, David N. Hernandez, Hanane El Bannoudi, William E. Sause, Alexis Sommerfield, Isaac P. Thomsen, Andy O. Miller, Victor J. Torres, Gregg J. Silverman   +18 more
doaj   +1 more source

Atypical Presentation of Methicillin-Susceptible Staphylococcus aureus Infection in a Dengue-Positive Patient: A Case Report with Virulence Genes Analysis

Pathogens, 2020
Concurrent bacteraemia in patients with dengue fever is rarely reported. We report a case of a patient who initially presented with symptoms typical of dengue fever but later succumbed to septic shock caused by hypervirulent methicillin-susceptible ...
Soo Tein Ngoi, Yee Wan Lee, Wen Kiong Niek, Foong Kee Kan, Sazaly AbuBakar, Sasheela Sri La Sri Ponnampalavanar, Nuryana Idris, Cindy Shuan Ju Teh   +7 more
doaj   +1 more source

CASSETTE—clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: study protocol for a randomised controlled trial

Trials, 2019
Background Exotoxins are important virulence factors in Staphylococcus aureus. Clindamycin, a protein synthesis inhibitor antibiotic, is thought to limit exotoxin production and improve outcomes in severe S. aureus infections.
Ravindra Dotel, Steven Y. C. Tong, Asha Bowen, Jane N. Nelson, Matthew V. N. O’Sullivan, Anita J. Campbell, Brendan J. McMullan, Philip N. Britton, Joshua R. Francis, Damon P. Eisen, Owen Robinson, Laurens Manning, Joshua S. Davis   +12 more
doaj   +1 more source

Characterisation of Staphylococcus aureus Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes lukP/Q

Toxins
Leukocidins of Staphylococcus (S.) aureus are bicomponent toxins that form polymeric pores in host leukocyte membranes, leading to cell death and/or triggering apoptosis. Some of these toxin genes are located on prophages and are associated with specific
Stefan Monecke, Sindy Burgold-Voigt, Andrea T. Feßler, Martina Krapf, Igor Loncaric, Elisabeth M. Liebler-Tenorio, Sascha D. Braun, Celia Diezel, Elke Müller, Martin Reinicke, Annett Reissig, Adriana Cabal Rosel, Werner Ruppitsch, Helmut Hotzel, Dennis Hanke, Christiane Cuny, Wolfgang Witte, Stefan Schwarz, Ralf Ehricht   +18 more
doaj   +1 more source

Staphylococcus aureus Infection and Persistence in Chronic Rhinosinusitis: Focus on Leukocidin ED

Toxins, 2020
Chronic rhinosinusitis (CRS) is thought to be a multifactorial disease that includes a direct involvement of bacteria that trigger inflammation and contribute to CRS pathogenesis. Staphylococcus aureus infection and persistence is associated with chronic
Dimitri Poddighe, Luca Vangelista
doaj   +1 more source

Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria. [PDF]

PLoS ONE, 2017
Staphyloccus aureus is a major human pathogen leading frequently to sepsis and soft tissue infections with abscesses. Multiple virulence factors including several immune modulating molecules contribute to its survival in the host. When S.
Hanne Amdahl, Karita Haapasalo, Lydia Tan, Taru Meri, Pentti I Kuusela, Jos A van Strijp, Suzan Rooijakkers, T Sakari Jokiranta   +7 more
doaj   +1 more source

S. aureus hemolysins, bi-component leukocidins and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?

Frontiers in Cellular and Infection Microbiology, 2012
One key aspect of S. aureus virulence lies in its ability to target the host cell membrane with a large number of membrane-damaging toxins and peptides.
Francois eVandenesch, Francois eVandenesch, Francois eVandenesch, Gérard eLina, Gérard eLina, Gérard eLina, Thomas eHenry, Thomas eHenry   +7 more
doaj   +1 more source

Detection of Alpha-Toxin and Other Virulence Factors in Biofilms of Staphylococcus aureus on Polystyrene and a Human Epidermal Model. [PDF]

PLoS ONE, 2016
The ability of Staphylococcus aureus to successfully colonize (a)biotic surfaces may be explained by biofilm formation and the actions of virulence factors.
P M den Reijer, E M Haisma, N A Lemmens-den Toom, J Willemse, R I Koning, J A A Demmers, D H W Dekkers, E Rijkers, A El Ghalbzouri, P H Nibbering, W van Wamel   +10 more
doaj   +1 more source

Role of defensins in immunothrombosis

Rheumatology &Autoimmunity, EarlyView.
Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang, Guijuan Guo, Xiangjun Liu, Xiaoyu Chen, Wenqiong Wang, Patapong Towiwat, Ru Li, Chun Li   +7 more
wiley   +1 more source

Staphylococcus aureus Exotoxins and Their Detection in the Dairy Industry and Mastitis

Toxins, 2020
Staphylococcus aureus constitutes a major food-borne pathogen, as well as one of the main causative agents of mastitis in dairy ruminants. This pathogen can produce a variety of extracellular toxins; these include the shock syndrome toxin 1 (TSST-1 ...
Ana G. Abril, Tomás G. Villa, Jorge Barros-Velázquez, Benito Cañas, Angeles Sánchez-Pérez, Pilar Calo-Mata, Mónica Carrera   +6 more
doaj   +1 more source