Characterization of a leukocidin identified in Staphylococcus pseudintermedius. [PDF]
PLoS ONE, 2018 Bacterial infections from Staphylococcus pseudintermedius are the most common cause of skin infections (pyoderma) affecting dogs. Two component pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F
Mohamed A Abouelkhair +4 more
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Genomic insights into multidrug resistance and virulence of methicillin-resistant Staphylococcus pseudintermedius from companion animal otitis [PDF]
Frontiers in Veterinary ScienceStaphylococci are major opportunistic pathogens of companion animals and an important reservoir of antimicrobial resistance genes with zoonotic relevance.
Juliana Menezes +14 more
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SarS Is a Repressor of Staphylococcus aureus Bicomponent Pore-Forming Leukocidins [PDF]
Infection and Immunity, 2023 Mj Sullivan +2 more
exaly +2 more sources
mSphere, 2022 Nonhealing diabetic foot ulcers (DFU), a major complication of diabetes, are associated with high morbidity and mortality despite current standard of care. Since Staphylococcus aureus is the most common pathogen isolated from nonhealing and infected DFU,
Christine Tkaczyk +6 more
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Host–Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity
Toxins, 2020 Staphylococcal bi-component pore-forming toxins, also known as leukocidins, target and lyse human phagocytes in a receptor-dependent manner. S-components of the leukocidins Panton-Valentine leukocidin (PVL), γ-haemolysin AB (HlgAB) and CB (HlgCB ...
Angelino T. Tromp +13 more
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Identification of two neutralizing human single-chain variable fragment antibodies targeting Staphylococcus aureus alpha-hemolysin [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): The inability of the host immune system to defeat Staphylococcus aureus is due to various secreted virulent factors such as leukocidins, superantigens, and hemolysins, which interrupt the function of immune components.
Somayeh Piri-Gavgani +5 more
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The cell envelope of Staphylococcus aureus selectively controls the sorting of virulence factors
Nature Communications, 2021 The pathogen Staphylococcus aureus releases several pore-forming toxins, termed leukocidins, that kill immune cells. Here, Zheng et al. show that the retention of a leukocidin on bacterial cells and its release are modulated by lipoteichoic acid and a ...
Xuhui Zheng +6 more
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mBio, 2019 Staphylococcus aureus is a human pathogen responsible for high morbidity and mortality worldwide. Recurrent infections with this bacterium are common, suggesting that S. aureus thwarts the development of sterilizing immunity. S. aureus strains that cause
Evelien T. M. Berends +6 more
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Mode of Action of Staphylococcal Leukocidin: Relationship between Binding of 125 I-Labeled S and F Components of Leukocidin to Rabbit Polymorphonuclear Leukocytes and Leukocidin Activity [PDF]
Infection and Immunity, 1981 The binding of 125 I-labeled S component to rabbit polymorphonuclear leukocytes was found to be concentration dependent and saturable at 37°C. Scatchard analysis of the binding curve gave a straight line, indicating that S component binds to a single population of sites. The dissociation constant,
M, Noda +3 more
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Cell Reports, 2021 Summary: Skin is one of the most common sites of host immune response against Staphylococcus aureus infection. Here, through a combination of in vitro assays, mouse models, and intravital imaging, we find that S.
Jakub M. Kwiecinski +5 more
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