Results 161 to 170 of about 237,141 (361)
Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
Advanced Science, EarlyView.The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng +10 more
wiley +1 more source
Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
Advanced Science, EarlyView.This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang +6 more
wiley +1 more source
Screening of Hardhenu Crossbred, Sahiwal and Hariana Bulls for Autosomal Recessive Genetic Disorder Bovine Leukocyte Adhesion Deficiency (BLAD) [PDF]
, 2019 Ankit Magotra +3 more
openalex +1 more source
Advanced Science, EarlyView.Obese gut‐microbiota derived lipopolysaccharides (LPS) induce bone marrow macrophage senescence and GCA secretion via activating TLR4/NF‐κB/MAPKs pathway. Clinically, obese patients are associated with higher serum GCA levels. Mice with depletion of GCA gene show resistance to skeletal deterioration caused by obesity and LPS‐induced chronic ...
Min Huang +16 more
wiley +1 more source
Advanced Science, EarlyView.The deficient TiO2 (DTO) and Barium titanate (BTO) heterojunction treats osteomyelitis through SDT. The spin‐polarization effect induced by the unpaired spin electrons in Ti atoms can expedite the transfer of ultrasonic piezoelectric charges in BTO, enhancing surface sonocatalytic efficiency.
Chaofeng Wang +10 more
wiley +1 more source
Advanced Science, EarlyView.The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang +13 more
wiley +1 more source
Advanced Science, EarlyView.Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou +17 more
wiley +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Inhibition of tissue factor expression by hydroxyurea in polymorphonuclear leukocytes from patients with myeloproliferative disorders: a new effect for an old drug? [PDF]
, 2006 Norma Maugeri +7 more
openalex +1 more source