Results 51 to 60 of about 8,876 (143)

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

The Role of EVs in the Aging Hematopoietic System

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent, Nathalie Havranek, Karoline Kollmann, Kristina Kirschner, Eszter Doma, Kavya Gupta   +5 more
wiley   +1 more source

Leukocyte Telomere Length and Serum Levels of High-Molecular-Weight Adiponectin and Dehydroepiandrosterone-Sulfate Could Reflect Distinct Aspects of Longevity in Japanese Centenarians

Gerontology and Geriatric Medicine, 2017
Leukocyte telomere length and serum levels of high-molecular-weight adiponectin and dehydroepiandrosterone-sulfate (DHEA-S) were assessed in association with nutrition and performance status (PS) in Japanese centenarians.
Yuji Aoki MD, PhD, Masato Aoki BSc, Kazuya Yamada PhD   +2 more
doaj   +1 more source

Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. [PDF]

PLoS Genetics, 2012
Telomerase activity is readily detectable in extracts from human hematopoietic stem and progenitor cells, but appears unable to maintain telomere length with proliferation in vitro and with age in vivo.
Geraldine Aubert, Gabriela M Baerlocher, Irma Vulto, Steven S Poon, Peter M Lansdorp   +4 more
doaj   +1 more source

A Deep‐Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes

Aging Cell, Volume 25, Issue 10, October 2026.
Using 38 blood SASP proteins, a guided autoencoder‐transformer model generates a composite SASP Score that captures systemic cellular senescence burden. The score predicts mortality and age‐related diseases, outperforms individual proteins, and supports cross‐platform biomarker translation.
Shangshu Zhao, Chia‐Ling Kuo, Eric J. Lenze, Julie L. Wetherell, Laura Haynes, Perla El‐Ahmad, Richard Fortinsky, George Kuchel, Trevor Harris, Breno S. Diniz   +9 more
wiley   +1 more source

Changes in leukocyte telomere length following comprehensive cardio-oncology rehabilitation in breast cancer survivors: A pilot randomized prospective study

Кубанский научный медицинский вестник
Background. Cardiotoxic anticancer treatment increases cardiovascular risk and may exacerbate cellular senescence in breast cancer patients. Cardio-oncology rehabilitation can be a promising strategy to reduce this risk in breast cancer survivors.
M. V. Vitsenya, I. V. Barinova, N. A. Doroshchuk, Z. B. Khasanova, O. O. Frolkova, N. V. Pogosova   +5 more
doaj   +1 more source

The Baboon as a Model to Study Human Health and Complex Disease

American Journal of Primatology, Volume 88, Issue 9, September 2026.
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley   +1 more source

Association between telomere length in peripheral blood leukocytes and risk of ischemic stroke in a Han Chinese population: a linear and non-linear Mendelian randomization analysis

Journal of Translational Medicine, 2020
Background Many contradictory conclusions pertaining to the telomere length in peripheral leukocyte chromosomes as a potential biomarker for ischemic stroke (IS) risk have been reported by the various observational studies in previous years.
Weijie Cao, Deqiang Zheng, Jie Zhang, Anxin Wang, Di Liu, Jinxia Zhang, Manjot Singh, Isinta Elijah Maranga, Mingyang Cao, Lijuan Wu, Manshu Song, Wei Wang, Youxin Wang   +12 more
doaj   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Metabolic Profiling of Epigenetic Aging and Its Associations With Aging‐Related Phenotypes and Modifiable Lifestyle Factors

Aging Cell, Volume 25, Issue 9, September 2026.
This study provides novel insights into the metabolic correlates of epigenetic aging biomarkers and underscores the potential of metabolomics‐informed metrics of epigenetic aging as informative indicators of physiological decline and lifestyle effects.
Xunying Zhao, Tianpei Ma, Maoyao Xia, Xinyang Dui, Yangdan Zhong, Xin Chen, Yang Qu, Bowen Lei, Qingwen Zhao, Xueyao Wu, Haiyu Yan, Xingyu Zhang, Ke Jiang, Lin Hu, Lu Long, Mengyu Fan, Jiaqiang Liao, Tao Zhang, Xia Jiang, Jiayuan Li, Ben Zhang   +20 more
wiley   +1 more source