Results 61 to 70 of about 8,876 (143)

hTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle‐Activating Capacity

Aging Cell, Volume 25, Issue 9, September 2026.
hTERT immortalization stabilizes hUCMSC‐derived sEV function by alleviating cellular senescence and preserving young‐like cargo profiles. H11‐sEVs retain immunomodulatory activity, primordial follicle‐activating capacity, and ovarian protective effects.
Yating Chen, Wei Liu, Ying Tian, Xinyu Wang, Haonan Fan, Mingyu Yang, Feiyang Diao, Jing Li   +7 more
wiley   +1 more source

Associations Between Accelerometer‐Assessed Sleep Patterns, Proteomic Signatures, and Hallmarks of Aging in Adulthood

Aging Cell, Volume 25, Issue 9, September 2026.
Objectively measured sleep patterns were associated with multiple hallmarks of aging. Total sleep duration, deep sleep, and REM sleep were generally associated with lower risks , whereas longer WASO and sleep irregularity were associated with higher risks. Integrating objective sleep phenotyping with large‐scale proteomics, we identified shared protein
Ruiyi Liu, Jingsong Luo, Yangchang Zhang, Furong Wang, Jing Xu, Wangnan Cao, Shengzhi Sun   +6 more
wiley   +1 more source

Integrative Analysis Uncover the Effects and Multi‐Omics Features of Thigh Muscle Fat Infiltration

Aging Cell, Volume 25, Issue 9, September 2026.
Thigh muscle fat infiltration (TMFI), estimated from MRI, is associated with increased mortality and diseases affecting multiple organ systems and mediates the effects of lifestyle factors on health. Multi‐omics analyses delineate the genetic, cellular, transcriptional, proteomic, and metabolic architecture of TMFI.
Yiwei Zhang, Qin Dang, Xizeng Zong, Haowei Chen, Simin Wen, Siqi Xu, Kunyan Wang, Xiaoshuai Wang, Jianwei Zhu, Zhaohua Zhu, Changhai Ding, Guangfeng Ruan, Yan Zhang   +12 more
wiley   +1 more source

Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition

Critical Care, 2018
Background Children who have suffered from critical illnesses that required treatment in a paediatric intensive care unit (PICU) have long-term physical and neurodevelopmental impairments. The mechanisms underlying this legacy remain largely unknown.
Sören Verstraete, Ilse Vanhorebeek, Esther van Puffelen, Inge Derese, Catherine Ingels, Sascha C. Verbruggen, Pieter J. Wouters, Koen F. Joosten, Jan Hanot, Gonzalo G. Guerra, Dirk Vlasselaers, Jue Lin, Greet Van den Berghe   +12 more
doaj   +1 more source

Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Subhasri Biswas, Hoang V. M. Nguyen, Aubrey Converse, Satoshi Matsuzaki, Michael T. Kinter, Kenneth M. Humphries, Willard M. Freeman, Sarah R. Ocañas, Arlan Richardson, Francesca E. Duncan, Tommy L. Lewis Jr, Michael B. Stout   +11 more
wiley   +1 more source

Human iPSC‐Derived Brain Organoids: A Disease‐Oriented Evaluation of Modeling Fidelity

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
Organoids are self‐organizing 3D structures that mimic organ architecture and function with multiple cell types arranged in spatial patterns. Brain organoids can be patterned towards specific regions and can incorporate glial and microglial components.
Bishwa R. Pokharel, Abigail Dickerson, Sanjana G. Shenoy, Mira S. Ramasamy, Niska Majumdar, Paul P. Cook, Shaw M. Akula   +6 more
wiley   +1 more source

Leukocyte Telomere Length and Cardiac Structure and Function: A Mendelian Randomization Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Existing research demonstrates the association of shorter leukocyte telomere length with increased risk of age‐related health outcomes including cardiovascular diseases.
Ahmed M. Salih, Ilaria Boscolo Galazzo, Gloria Menegaz, André Altmann   +3 more
doaj   +1 more source

Dietary Copper Intake and Its Association With Telomere Length: A Population Based Study

Frontiers in Endocrinology, 2018
Background: Telomere is regarded as the fundamental aspect of cellular aging and copper is recognized as one of the most essential trace elements. The role of dietary copper intake in telomere length maintenance is seldom examined.
Zhu Lin, Hongmei Gao, Bing Wang, Yongqiang Wang   +3 more
doaj   +1 more source

Prmt6 Deficiency Drives Osteoblast Senescence Promoting Age‐Related Osteoporosis via Epigenetic Remodelling of the H3R2me2a/Sting/Ifitm3 Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Protein arginine methyltransferase 6 (Prmt6), an epigenetic regulator, plays an unclear role in bone homeostasis and osteoblast senescence. In this study, we employed Western blot, qPCR, immunofluorescence, SA‐β‐Gal staining, and RNA‐seq to systematically investigate the regulatory mechanism of the Prmt6/H3R2me2a/Sting/Ifitm3 axis in ...
Yuxue Wang, Xiaoyong Ge, Shengjie Chang, Diankai Wang, Ke Xu, Haowei Xu, Xiaowei Liu, Shanjin Wang   +7 more
wiley   +1 more source

Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern, Traver J. Wright, Erik D. Marchant, Sean P. Kilroe, William J. Durham, E. Lichar Dillon, Marc M. Baum, Michael P. Kinsky, William K. Russell, Christopher S. Fry, Pratik Gongloor, Richard B. Pyles, Randall J. Urban, Blake B. Rasmussen, Melinda Sheffield‐Moore   +14 more
wiley   +1 more source