Results 101 to 110 of about 128,249 (313)
Advanced Science, EarlyView.A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou +10 more
wiley +1 more source
Бюллетень сибирской медицины, 2011 Score mRNA expression and the level of Hsp27 (Heat shock protein 27) and phospho-Hsp27 in tumor cell line Jurkat and THP-1, as well as in mononuclear leukocytes obtained from healthy donors was investigated.
Ye. V. Kaigorodova
doaj +1 more source
Differential and Temporal Immunomodulation of alpha4 Integrins on CD4+ Memory Cells by Bordetella pertussis and Bordetella parapertussis [PDF]
, 2012 Pertussis, caused by Bordetella pertussis (B. pertussis), is reemerging worldwide due to vaccine inefficacy. The hallmarks of infection are extreme lymphocytosis and delayed recovery, which are partially associated with pertussis toxin.
Ravindra, Dipti
core +1 more source
Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]
, 2009 The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S +2 more
core +1 more source
Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes
Advanced Science, EarlyView.This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang +8 more
wiley +1 more source
The Cytotoxic Effects of Sio2 Nanoparticles on Human Blood Mononuclear Cells
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2012 Introduction: Regarding the increasing use of silicon dioxide nanoparticles in medical biotechnology and probable side effects and diseases resulting from its usage, this study was performed to assess the toxic effects of different concentrations of SiO2
A Jebali +4 more
doaj
Hepcidin and Host Defense against Infectious Diseases. [PDF]
, 2015 Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas +3 more
core +1 more source
Advanced Science, EarlyView.This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song +10 more
wiley +1 more source
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Case Reports in Veterinary MedicineMost dogs with nonerosive immune-mediated polyarthritis (IMPA) have neutrophilic inflammation in the synovial fluid. On the other hand, some dogs with erosive IMPA have increased mononuclear cells as the most abundant cell subset in the synovial fluid. A
Kohei Murakami +5 more
doaj +1 more source